Table 1

Numbers of biological replicates

ExperimentDrug administeredExperiment dayNumbers of animals analyzed/used (sex)Body
weight (g)
MRIPBS75/6* (male)26.4 ± 2.0
HPSPNP311/12** (male)
2/2 (female)
26.7 ± 0.7
18.7 ± 0.3
76/7** (male)
2/2 (female)
26.7 ± 0.9
18.6 ± 0.1
PDGF-BB75/5 (male)27.0 ± 1.8
PDGF-B HSPNP (low)75/5 (male)24.1 ± 1.0
PDGF-B HSPNP313/13 (male)
2/2 (female)
27.0 ± 2.5
18.2 ± 0.2
78/9* (male)
2/2 (female)
27.6 ± 2.4
18.1 ± 0.2
Cylinder testPBS75/6* (male)26.4 ± 2.0
HPSPNP38/9** (male)26.5 ± 0.4
75/6** (male)26.3 ± 0.4
PDGF-BB75/5 (male)27.0 ± 1.8
PDGF-B HSPNP (low)75/5 (male)24.1 ± 1.0
PDGF-B HSPNP312/12 (male)26.9 ± 2.6
78/9** (male)27.6 ± 2.4
Western blottingHSPNP32/2 (male)27.0 ± 0.3
73/3 (male)27.2 ± 1.0
PDGF-B HSPNP32/2 (male)23.5 ± 1.1
74/4 (male)25.7 ± 1.9
ImmunostainingHSPNP32/2 (male)26.3 ± 0.0
sample75/5 (male)26.3 ± 0.4
PDGF-B HSPNP34/4 (male)25.9 ± 2.5
75/5 (male)25.3 ± 2.1
Pilot behavioral experiment
using the IVIS
1, 3, 7, 1525/32 (male)
(*, 4; **, 1; ***, 2)
25.1 ± 2.8
Cumulative total161/176
  • Body weight values are shown as mean ± SD. The exclusion criteria were as follows: *, premature death; **, hemorrhagic infarction on MRI; ***, failure of surgery. PBS, vehicle; HSPNPs, heat shock protein nanoparticles; PDGF-BB, dimer of PDGF B; PDGF-B HSPNPs, PDGF B conjugated to HSPNPs, dose = 1.04 μmol/l; PDGF-B HSPNPs (low), same but dose = 0.104 μmol/l.