Table 1

Summary of mouse Brs3 allele phenotypes

  C57BL/6JBRS3-CreERBRS3-IRES-CreBRS3-null
Body weight ReferenceIncreasedIncreasedIncreased
Body temperature span ReferenceNo changeNo changeIncreased
Reporter expression in adult Ai14 miceHypothalamus YesYes 
Parabrachial nucleus YesYes 
Hippocampus NoYes 
Striatum NoYes 
Hypothalamus Brs3 RNA 100%43%7%None
Food intake inhibition by BRS3 agonist, MK-5046 YesIntactLostLost
Body temperature increase by BRS3 agonist, MK-5046 YesIntactBluntedLost
  • BRS3-IRES-Cre observations are presented in Results; BRS3-CreER data are from Results and the study by Piñol et al. (2018); and the BRS3-null phenotype is from the studies by Ohki-Hamazaki et al. (1997b), Guan et al. (2011), and Xiao et al. (2017), among others.