Top 10 differentially regulated genes by αSyn 3K in primary neuron cultures
| Rank | Gene name | log2FC | Combined FDR p value |
|---|---|---|---|
| 1 | Lpcat1 | 0.84 | 2.64E-86 |
| 2 | Rnf145 | 0.61 | 5.14E-35 |
| 3 | Rgs4 | 0.44 | 2.02E-17 |
| 4 | Scd1 | −0.67 | 5.96E-13 |
| 5 | Fam102b | 0.84 | 8.20E-12 |
| 6 | Acsbg1 | −0.25 | 1.34E-10 |
| 7 | Snn | 0.45 | 5.31E-10 |
| 8 | Psat1 | −0.29 | 1.34E-09 |
| 9 | Rgcc | −0.4 | 1.07E-08 |
| 10 | Pcdh8 | 0.26 | 2.01E-08 |
A meta-analysis was performed to identify the top differentially regulated genes at 6, 12, and 19 d after AAV9 transduction time points. These are the top 10 genes from this meta-analysis (see Extended Data Table 1-1 for the full results, and Extended Data Table 1-2 for pathway analysis); p values are corrected for false discovery (for details, see Materials and Methods).