Table 2

AAL Regions displaying the greatest difference between baseline approximations and longitudinal measurements

		Coordinates
Domain	Age group	x	y	z	AAL region	Hem	MAE	N. ROIs
MEM	Young	−24	57	3	Superior frontal gyrus (DL)	L	35.65	57
		−27	54	3	Middle frontal gyrus	L	31.06	132
		−30	54	−3	Superior frontal gyrus (ORB)	L	30.96	2
	Middle	−42	−63	−24	Cerebellum crus 1	L	29.46	16
		−21	63	12	Superior frontal gyrus (DL)	L	28.64	48
		−42	−57	−24	Cerebellar crus 6	L	28.41	56
	Old	30	−84	−18	Lingual gyrus	R	39.74	94
		36	−84	−15	Inferior occipital lobe	R	37.86	56
		27	−84	−18	Cerebellar crus 1	R	37.58	47
FLUID	Young	−21	63	9	Superior frontal gyrus (DL)	L	28.22	61
		−9	63	12	Superior frontal gyrus (Med)	L	21.89	157
		−27	57	12	Middle frontal gyrus	L	19.84	64
	Middle	−9	45	−9	Superior frontal gyrus (MedOrb)	L	22.64	10
		−6	33	−6	Cingulate gyrus (Ant)	L	21.20	73
		6	39	−9	Superior frontal gyrus (MedOrb)	R	20.71	9
	Old	39	−69	−24	Cerebellar crus 1	R	20.15	63
		−42	−63	−24	Cerebellar crus 1	L	18.64	16
		36	−72	−21	Cerebellar crus 6	R	17.19	111
SPEED	Young	−45	45	−9	Inferior frontal gyrus (ORB)	L	21.61	30
		−42	45	−6	Middle frontal gyrus (Orb)	L	20.05	18
		36	54	6	Middle frontal gyrus	R	18.70	105
	Middle	−30	54	−3	Superior frontal gyrus (Orb)	L	18.49	2
		−33	54	−3	Middle frontal gyrus (Orb)	L	17.99	18
		18	−93	−12	Lingual gyrus	R	16.02	49
	Old	24	36	−21	Middle frontal gyrus (Orb)	R	19.17	8
		36	−90	0	Inferior occipital lobe	R	18.75	52
		36	−90	3	Middle occipital lobe	R	18.66	42
VOCAB	Young	−39	51	−6	Middle frontal gyrus (Orb)	L	33.88	18
		−30	54	−3	Superior frontal gyrus (Orb)	L	33.36	2
		−33	54	0	Superior frontal gyrus (DL)	L	32.88	40
	Middle	30	−90	9	Middle occipital lobe	R	23.33	88
		15	−96	3	Calcarine fissure + surrounding cortex (V1)	R	21.23	23
		39	−69	−24	Cerebellar crus 1	R	20.26	51
	Old	36	−90	3	Middle occipital lobe	R	32.27	103
		36	−90	0	Inferior occipital lobe	R	30.82	92
		39	−69	−24	Inferior occipital lobe	R	24.29	27

The three regions per age bracket and domain displaying the greatest difference, via MAE metric at the >97.5 percentile, are presented. Coordinates refer to the center voxel of the ROI. As MAE is a negative-oriented error metric, higher values indicate higher differences. The “N.ROIs” column represents the number of ROIs in the >97.5 percentile subset (601 ROIs/comparison) for which the left voxel is located in the AAL (automated anatomical labeling) region listed. For instance, in the case of the first row entry, the left dorsolateral superior frontal gyrus displayed the greatest difference at x, y, and z locations (−24, 57, and 3), but this region was among the top 601 ROIs displaying the greatest differences for 57 of the 601 ROIs. Hem, Hemisphere; L, left; R, right; DL, dorsolateral; Orb, orbital; Med, medial.