Table 5

ROIs Denoted by AAL area expressing the greatest integrated negative change for longitudinal measurements

		Coordinates
Domain	Age group	x	y	z	AAL region	Hem	Integral	N. ROIs
MEM	Young	−24	57	3	Superior frontal gyrus (DL)	L	−580.56	69
		−27	54	3	Middle frontal gyrus	L	−523.74	179
		−30	54	−3	Superior frontal gyrus (Orb)	L	−516.44	2
	Middle	−30	54	−3	Superior frontal gyrus (Orb)	L	−445.79	2
		−33	54	−3	Middle frontal gyrus (Orb)	L	−405.77	18
		−30	54	3	Middle frontal gyrus	L	−379.80	115
	Old	−51	15	36	Inferior frontal gyrus (opercular)	L	−294.61	30
		−48	18	39	Middle frontal gyrus	L	−288.31	78
		−51	12	39	Precentral gyrus	L	−269.83	23
FLUID	Young	36	9	60	Middle frontal gyrus	R	−105.61	269
		51	12	42	Precentral gyrus	R	−82.72	77
		51	15	39	Inferior frontal gyrus (opercular)	R	−78.94	110
	Middle	36	9	60	Middle frontal gyrus	R	−100.77	266
		51	12	42	Precentral gyrus	R	−78.12	83
		51	15	39	Inferior frontal gyrus (opercular)	R	−74.91	104
	Old	45	15	48	Middle frontal gyrus	R	−72.82	277
		39	−21	−27	Fusiform	R	−64.45	18
		51	18	39	Inferior frontal gyrus (opercular)	R	−63.05	107
SPEED	Young	−42	45	−9	Inferior frontal gyrus (Orb)	L	−471.46	38
		−42	45	−6	Middle frontal gyrus (Orb)	L	−452.86	18
		36	51	6	Middle frontal gyrus	R	−400.16	176
	Middle	45	45	6	Middle frontal gyrus	R	−317.70	172
		42	45	0	Inferior frontal gyrus (triangular)	R	−292.00	236
		42	45	−3	Inferior frontal gyrus (Orb)	R	−278.74	53
	Old	−45	45	−9	Inferior frontal gyrus (Orb)	L	−297.48	53
		−48	39	0	Inferior frontal gyrus (triangular)	L	−274.64	47
		45	45	6	Middle frontal gyrus	R	−222.84	187
VOCAB	Young	−42	45	−9	Inferior frontal gyrus (Orb)	L	−445.70	28
		−39	48	−6	Middle frontal gyrus (Orb)	L	−424.14	18
		−42	51	3	Middle frontal gyrus	L	−346.89	148
	Middle	36	51	6	Middle frontal gyrus	R	−324.85	185
		−42	51	6	Middle frontal gyrus	L	−251.18	178
		−42	48	6	Inferior frontal gyrus (triangular)	L	−243.30	44
	Old	−42	45	−9	Inferior frontal gyrus (Orb)	L	−320.47	40
		−42	45	−6	Middle frontal gyrus (Orb)	L	−286.34	18
		−48	42	0	Inferior frontal gyrus (triangular)	L	−224.47	187

The three regions per age bracket and domain displaying the greatest integrated negative change at the <2.5 percentile, are presented. Integrated change was calculated via trapezoidal summation in the segmented age bracket. Coordinates refer to the left voxel of the ROI. Lower values signify greater negative change. The “N.ROIs” column represents the number of ROIs in the <2.5 percentile subset (601 ROIs per comparison) for which the center voxel is located in the AAL (automated anatomical labeling) region listed. For instance, in the case of the first row entry, the left dorsolateral superior frontal gyrus displayed the greatest negative change at x, y, and z locations (−27, 57, and 3), but this region was among the top 601 ROIs displaying the greatest negative change for 69 of the 601 ROIs. Hem, Hemisphere; L, left; R, right; DL, dorsolateral; Med, medial; Ant, anterior; Med, medial.