Table 3

ROIs Denoted by AAL area displaying the greatest similarity between baseline approximations and longitudinal measurements

		Coordinates
Domain	Age group	x	y	z	AAL region	Hem	MAE	N. ROIs
MEM	Young	−27	3	0	Putamen	L	0.42	109
		15	−6	66	Superior frontal gyrus (DL)	R	0.47	27
		51	−39	54	Inferior parietal gyrus	R	0.49	43
	Middle	15	−84	39	Cuneus	R	1.28	26
		42	−51	57	Superior parietal gyrus	R	1.58	17
		−6	−69	48	Precuneus	L	1.65	72
	Old	63	−33	24	Superior temporal gyrus	R	0.22	92
		60	−33	27	Supramarginal gyrus	R	0.28	80
		42	21	48	Middle frontal gyrus	R	0.39	41
FLUID	Young	−30	12	−9	Undefined	L	0.37	111
		48	−75	30	Middle occipital lobe	R	0.38	31
		−12	6	63	Supplementary motor area	L	0.38	11
	Middle	36	−36	54	Postcentral Gyrus	R	0.21	14
		39	−66	42	Angular Gyrus	R	0.23	105
		30	9	9	Putamen	R	0.27	14
	Old	33	−12	−27	Parahippocampal	R	0.33	28
		21	24	60	Superior frontal gyrus (DL)	R	0.39	51
		36	−15	−21	Hippocampus	R	0.42	18
SPEED	Young	6	−60	36	Precuneus	R	0.29	96
		39	21	−6	Insula	R	0.36	28
		−18	−33	6	Undefined	L	0.37	24
	Middle	12	15	60	Supplementary motor area	R	0.24	35
		66	−27	15	Superior temporal gyrus	R	0.28	56
		30	9	51	Middle frontal gyrus	R	0.28	69
	Old	−57	−18	45	Inferior parietal gyrus	L	0.23	5
		−3	12	36	Cingulate gyrus (Mid)	L	0.26	26
		−24	12	51	Middle frontal gyrus	L	0.32	44
VOCAB	Young	−6	−3	−9	Undefined	L	0.34	138
		−15	3	15	Caudate	L	0.52	59
		15	0	18	Caudate	R	0.95	34
	Middle	−6	18	30	Cingulate gyrus (Ant)	L	0.34	36
		3	18	27	Cingulate gyrus (Ant)	R	0.37	22
		−45	6	30	Inferior frontal gyrus (opercular)	L	0.44	60
	Old	18	36	48	Superior frontal gyrus (DL)	R	0.22	49
		−6	30	48	Superior frontal gyrus (Med)	L	0.27	32
		9	33	51	Superior frontal gyrus (Med)	R	0.27	42

The three regions per age bracket and domain displaying the greatest similarity, via MAE metric at the <2.5 percentile, are presented. Coordinates refer to the left voxel of the ROI. As MAE is a negative-oriented error metric, lower values indicate higher similarity. The “N.ROIs” column represents the number of ROIs in the <2.5 percentile subset (601 ROIs per comparison) for which the center voxel is located in the AAL (automated anatomical labeling) region listed. For instance, in the case of the first row entry, the left putamen displayed the greatest similarity at x, y, and z locations (−27, 3, and 0), but this region was among the top 601 ROIs displaying the greatest differences for 109 of the 601 ROIs. Hem, Hemisphere; L, Left; R, right; DL, dorsolateral; Med, medial; Ant, anterior; Mid, middle.