Table 1

Equations governing the voltage dependence and kinetics of currents in the model

Current general equations (except for ISK)
I(V,t)=gmax×ma(V,t)×hb(V,t)×(VErev)
m(V)=1(1+exp[((VVm)km)])

dm(V,t)/dt=[m(V)m(V,t)]τm
h(V)=1(1+exp[((VVh)kh)])

dh(V,t)/dt=[h(V)h(V,t)]τh
dt = 20 μs
CurrentVm (mV)km (mV)aVh (mV)kh (mV)bErev (mV)Specific equations (τm and τh are expressed in ms)gmax(pS/μm2)
Soma and dendritesAISAxon
INa–2883–50–10160τm = 0.01+(0.33/(1+((V+20)/30)2))
τh = 0.7+(16/(1+((V+50)/8)2))
754000400
IKDR–3094--0–90τm = (4* exp(-(0.000729)*((V +32)2))) + 41504000400
IAVh+5071–78 to –62–71–90τm = τh/50
τh = 15-150
15–15000
IH–100 to –80–7.251--0–40τm = 556+ 1100* exp (-0.5*((V)/11.06)2)0.25–2.500
ICaL–3171--0120τm = 1/((-0.209*(v+39.26)
/(exp(-(v+39.26)/4.111)-1)+
(0.944*exp(-(v+15.38)/224.1))))
100
ISK------–90I(V,Cai)=gmax×O(Cai)×(VErev)
O(V) = (Cai)4 /((Cai)4 + (0.00019)4)
0.12500
Calcium buffering and pump (see Desthexe et al., 1993)