Data | Figure | Statistical test | Test values | p value |
---|---|---|---|---|
Immunofluorescence data: | ||||
VGLUT1-cre: | ||||
HA MFI | 1 | Mann–Whitney U test | Median EGFP: 22.09 Median CB: 57.90 N = 6, U = 0 | 0.0022 |
CB integrated FI | 1 | Mann–Whitney U test | Median EGFP: 283.3 Median CB: 384.7 N = 6, U = 5 | 0.0411 |
SO Geph size | 2 | Mann–Whitney U test | Median EGFP: 0.2559 Median CB: 0.3428 N = 6, U = 0 | 0.0022 |
SP Geph size | 2 | Mann–Whitney U test | Median EGFP: 0.1923 Median CB: 0.2491 N = 6, U = 2 | 0.0087 |
SR Geph size | 2 | Mann–Whitney U test | Median EGFP: 0.2360 Median CB: 0.2838 N = 6, U = 4 | 0.0260 |
SO Geph density | 2 | Mann–Whitney U test | Median EGFP: 0.1133 Median CB: 0.1691 N = 6, U = 1 | 0.0043 |
SP Geph density | 2 | Mann–Whitney U test | Median EGFP: 0.0723 Median CB: 0.1331 N = 6, U = 3 | 0.0152 |
SR Geph density | 2 | Mann–Whitney U test | Median EGFP: 0.1136 Median CB: 0.1922 N = 6, U = 3 | 0.0152 |
SO γ2 size | 2 | Mann–Whitney U test | Median EGFP: 0.1760 Median CB: 0.1715 N = 6, U = 11 | 0.8413 |
SP γ2 size | 2 | Mann–Whitney U test | Median EGFP: 0.1647 Median CB: 0.2013 N = 6, U = 2 | 0.0317 |
SR γ2 size | 2 | Mann–Whitney U test | Median EGFP: 0.1522 Median CB: 0.1562 N = 6, U = 10 | 0.6905 |
SO γ2 density | 2 | Mann–Whitney U test | Median EGFP: 0.0879 Median CB: 0.0975 N = 6, U = 12 | >0.9999 |
SP γ2 density | 2 | Mann–Whitney U test | Median EGFP: 0.0865 Median CB: 0.0824 N = 6, U = 12 | >0.9999 |
SR γ2 density | 2 | Mann–Whitney U test | Median EGFP: 0.0615 Median CB: 0.0877 N = 6, U = 6 | 0.2222 |
SO VGAT size | 2 | Mann–Whitney U test | Median EGFP: 0.2082 Median CB: 0.2406 N = 6, U = 9 | 0.1797 |
SP VGAT size | 2 | Mann–Whitney U test | Median EGFP: 0.2447 Median CB: 0.2910 N = 6, U = 10 | 0.2403 |
SR VGAT size | 2 | Mann–Whitney U test | Median EGFP: 0.2015 Median CB: 0.2072 N = 6, U = 12 | 0.3939 |
SO VGAT density | 2 | Mann–Whitney U test | Median EGFP: 0.0594 Median CB: 0.0716 N = 6, U = 10 | 0.2229 |
SP VGAT density | 2 | Mann–Whitney U test | Median EGFP: 0.0705 Median CB: 0.0799 N = 6, U = 7 | 0.0931 |
SR VGAT density | 2 | Mann–Whitney U test | Median EGFP: 0.0778 Median CB: 0.0787 N = 6, U = 16 | 0.8182 |
VGAT-cre | ||||
HA MFI | 1 | Mann–Whitney U test | Median EGFP: 25.93 Median CB: 128.9 N = 4, U = 0 | 0.0286 |
CB integrated FI | 1 | Mann–Whitney U test | Median EGFP: 450.8 Median CB: 580.9 N = 4, U = 0 | 0.0286 |
Geph size | 3 | Mann–Whitney U test | Median EGFP: 0.1788 Median CB: 0.3437 N = 4, U = 0 | 0.0286 |
Geph density | 3 | Mann–Whitney U test | Median EGFP: 0.2291 Median CB: 0.4403 N = 4, U = 0 | 0.0286 |
γ2 size | 3 | Mann–Whitney U test | Median EGFP: 0.1706 Median CB: 0.2151 N = 4, U = 1 | 0.0571 |
γ2 density | 3 | Mann–Whitney U test | Median EGFP: 0.1387 Median CB: 0.1386 N = 4, U = 8 | >0.9999 |
VGAT size | 3 | Mann–Whitney U test | Median EGFP: 0.3144 Median CB: 0.3617 N = 4, U = 4 | 0.3429 |
VGAT density | 3 | Mann–Whitney U test | Median EGFP: 0.2008 Median CB: 0.2967 N = 4, U = 5 | 0.4857 |
Electrophysiology data | ||||
mIPSC amplitude cumulative frequency | 4 | Kolmogorov–Smirnov test | Kolmogorov–Smirnov D = 0.3283 N = 600, 500 | <0.0001 |
mIPSC amplitude | 4 | Mann–Whitney U test | Median EGFP: −29.84 Median CB: −41.98 N = 6, 5, U = 4 | 0.0455 |
mIPSC frequency cumulative frequency | 4 | Kolmogorov–Smirnov test | Kolmogorov–Smirnov D = 0.1651 N = 600, 500 | <0.0001 |
mIPSC frequency | 4 | Mann–Whitney U test | Median EGFP: 0.2125 Median CB: 0.4583 N = 6, 5, U = 0 | 0.0043 |
mIPSC rise time | 4 | Mann–Whitney U test | Median EGFP: 0.9404 Median CB: 1.127 N = 6, 5, U = 0 | 0.0043 |
mIPSC decay Tau | 4 | Mann–Whitney U test | Median EGFP: 15.22 Median CB: 18.40 N = 6, 5, U = 6 | 0.1255 |
Behavioral data | ||||
Cumulative seizure score | 5 | Kolmogorov–Smirnov test | Kolmogorov–Smirnov D = 0.7333 N = 12, 15 | 0.0006 |
Latency to seizure score 1 | 5 | Unpaired t test | Mean EGFP: 76.42 Mean CB: 216.1 N = 12, 14, F = 55.84, DFn = 13, Dfd = 11 | 0.0358 |
Latency to seizure score 2 | 5 | Unpaired t test | Mean EGFP: 83.33 Mean CB: 260.0 N = 12, 14, F = 90.32, DFn = 13, Dfd = 11 | 0.0480 |
Latency to seizure score 3 | 5 | Unpaired t test | Mean EGFP: 108.4 Mean CB: 252.5 N = 12, 11, F = 45.64, DFn = 10, Dfd = 11 | 0.0912 |
Latency to seizure score 4 | 5 | Unpaired t test | Mean EGFP: 167.6 Mean CB: 269.9 N = 12, 9, F = 5.961, DFn = 8, Dfd = 11 | 0.1815 |
Latency to seizure score 5 | 5 | Unpaired t test | Mean EGFP: 210.5 Mean CB: 381.0 N = 10, 5, F = 10.95, DFn = 4, Dfd = 9 | 0.1062 |
Latency to seizure score 6 | 5 | Unpaired t test | Mean EGFP: 239.9 Mean CB: 298.0 N = 9, 2, F = n/a, DFn = n/a, Dfd = n/a | 0.5353 |
Contingency seizure score 1 | 5 | Fisher’s exact test | EGFP: 12, 0 CB: 14, 1 Total: 26, 1 (seized, did not) | >0.9999 |
Contingency Seizure score 2 | 5 | Fisher’s exact test | EGFP: 12, 0 CB: 14, 1 Total: 26, 1 (seized, did not) | >0.9999 |
Contingency seizure score 3 | 5 | Fisher’s exact test | EGFP: 12, 0 CB: 11, 4 Total: 23, 4 (seized, did not) | 0.1060 |
Contingency seizure score 4 | 5 | Fisher’s exact test | EGFP: 12, 0 CB: 9, 6 Total: 21, 6 (seized, did not) | 0.0200 |
Contingency seizure score 5 | 5 | Fisher’s exact test | EGFP: 10, 5 CB: 5, 10 Total: 15, 12 (seized, did not) | 0.0185 |
Contingency seizure score 6 | 5 | Fisher’s exact test | EGFP: 9, 3 CB: 2, 13 Total: 11, 16 (seized, did not) | 0.0020 |