Table 1.

Basal properties of POMC neurons in slices from mice treated for 7 d with LDN or saline

Resting membrane
potential (mV)
Membrane
capacitance (pF)
Input resistance
(MΩ)
sPSC
frequency (Hz)
sPSC
amplitude (pA)
AP threshold
(mV)
AP frequency
(Hz)
Saline
mean ± SD
−39.44 ± 6.33
n = 10
23.65 ± 7.72
n = 32
820.8 ± 737.1
n = 32
8.789 ± 4.30
n = 33
59.86 ± 31.73
n = 33
−38.98 ± 5.78
n = 11
7.13 ± 4.08
n = 9
LDN
mean ± SD
−41.39 ± 11.30
n = 11
19.38 ± 6.12
n = 34
743.7 ± 699.1
n = 34
6.185 ± 4.16
n = 32
42.82 ± 23.64
n = 31
−41.89 ± 6.25
n = 12
5.24 ± 5.76
n = 11
p0.63550.01510.66420.01600.01830.26060.4190
t(df)0.4818 (19)2.498 (64)0.4362 (64)2.475 (63)2.424 (62)1.156 (21)0.827 (18)
  • Membrane capacitance, sPSC frequency, and sPSC amplitude were all lower in the LDN group as compared with saline (p > 0.05). Values are expressed as mean ± SD; n represents cell numbers. Total slices for each group: (columns 2–5) same as cell numbers, (columns 1, 6, 7) saline = 10, LDN = 9. Total mice for each group: (columns 2–5) saline = 21, LDN = 19; (columns 1, 6, 7) saline = 5, LDN = 4.