ARIMA model parameters for TMZ initiation in Figure 1B
| Estimate | Standard error | t value | p value | |||||
|---|---|---|---|---|---|---|---|---|
| ARIMA model parameters 1 | Outcomes | No transformation | Constant | 776.317 | 103.231 | 7.520 | <0.001 | |
| AR | Lag 1 | −0.297 | 0.326 | −0.910 | 0.386 | |||
| Time period | No transformation | Numerator | Lag 0 | −118.993 | 31.738 | −3.749 | 0.005 | |
| Phase | No transformation | Numerator | Lag 0 | −396.802 | 155.769 | −2.547 | 0.031 | |
| Interact | No transformation | Numerator | Lag 0 | 105.419 | 32.868 | 3.207 | 0.011 | |
| ARIMA model parameters 2 | ||||||||
| Outcomes | No transformation | Constant | 776.291 | 103.227 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.911 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 235.690 | 124.116 | 1.899 | 0.090 | |
| 6 months preintervention | No transformation | Numerator | Lag 0 | −118.985 | 31.736 | −3.749 | 0.005 | |
| 6 months postintervention | No transformation | Numerator | Lag 0 | −13.573 | 12.070 | −1.125 | 0.290 | |
| ARIMA model parameters 3 | ||||||||
| Outcomes | No transformation | Constant | 776.294 | 103.228 | 70.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.911 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 341.105 | 146.596 | 2.327 | 0.045 | |
| 12 months preintervention | No transformation | Numerator | Lag 0 | −118.986 | 31.736 | −3.749 | 0.005 | |
| 12 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.070 | −1.125 | 0.290 | |
| ARIMA model parameters 4 | ||||||||
| Outcomes | No transformation | Constant | 776.297 | 103.228 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.911 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 446.522 | 172.443 | 2.589 | 0.029 | |
| 18 months preintervention | No transformation | Numerator | Lag 0 | −118.987 | 31.736 | −3.749 | 0.005 | |
| 18 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.070 | −1.125 | 0.290 | |
| ARIMA model parameters 5 | ||||||||
| Outcomes | No transformation | Constant | 776.301 | 103.229 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.911 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 551.942 | 200.359 | 2.755 | 0.022 | |
| 24 months preintervention | No transformation | Numerator | Lag 0 | −118.988 | 31.737 | −3.749 | 0.005 | |
| 24 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.070 | −1.125 | 0.290 | |
| ARIMA model parameters 6 | ||||||||
| Outcomes | No transformation | Constant | 776.305 | 103.229 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.911 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 657.365 | 229.590 | 2.863 | 0.019 | |
| 30 months preintervention | No transformation | Numerator | Lag 0 | −118.989 | 31.737 | −3.749 | 0.005 | |
| 30 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.070 | −1.125 | 0.290 | |
| ARIMA model parameters 7 | ||||||||
| Outcomes | No transformation | Constant | 776.310 | 103.230 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.910 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 762.790 | 259.693 | 2.937 | 0.017 | |
| 36 months preintervention | No transformation | Numerator | Lag 0 | −118.991 | 31.737 | −3.749 | 0.005 | |
| 36 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.071 | −1.125 | 0.290 | |
| ARIMA model parameters 8 | ||||||||
| Outcomes | No transformation | Constant | 776.315 | 103.231 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.910 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 868.219 | 290.398 | 2.990 | 0.015 | |
| 42 months preintervention | No transformation | Numerator | Lag 0 | −118.992 | 31.737 | −3.749 | 0.005 | |
| 42 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.071 | −1.125 | 0.290 | |
| ARIMA model parameters 9 | ||||||||
| Outcomes | No transformation | Constant | 776.320 | 103.232 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.910 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 973.651 | 321.531 | 3.028 | 0.014 | |
| 48 months preintervention | No transformation | Numerator | Lag 0 | −118.994 | 31.738 | −3.749 | 0.005 | |
| 48 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.071 | −1.125 | 0.290 | |
| ARIMA model parameters 10 | ||||||||
| Outcomes | No transformation | Constant | 776.325 | 103.233 | 7.520 | <0.001 | ||
| AR | Lag 1 | −0.297 | 0.326 | −0.910 | 0.386 | |||
| Phase | No transformation | Numerator | Lag 0 | 1079.087 | 352.980 | 3.057 | 0.014 | |
| 54 months preintervention | No transformation | Numerator | Lag 0 | −118.995 | 31.738 | −3.749 | 0.005 | |
| 54 months postintervention | No transformation | Numerator | Lag 0 | −13.574 | 12.071 | −1.125 | 0.290 | |