Table 2

ARIMA model parameters for TMZ withdrawal in Figure 1B

					Estimate	Standard error	t value	p value
ARIMA model parameters 1	Outcomes	No transformation	Constant		82.121	47.138	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Time period	No transformation	Numerator	Lag 0	34.983	14.450	2.421	0.039
	Phase	No transformation	Numerator	Lag 0	327.730	75.612	4.334	0.002
	Interact	No transformation	Numerator	Lag 0	−49.690	15.668	−3.171	0.011
ARIMA model parameters 2
	Outcomes	No transformation	Constant		82.142	47.147	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	29.606	55.124	0.537	0.604
	6 months preintervention	No transformation	Numerator	Lag 0	34.977	14.453	2.420	0.039
	6 months postintervention	No transformation	Numerator	Lag 0	−14.705	6.041	−2.434	0.038
ARIMA model parameters 3
	Outcomes	No transformation	Constant		82.141	47.146	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−20.078	65.658	−0.306	0.767
	12 months preintervention	No transformation	Numerator	Lag 0	34.977	14.452	2.420	0.039
	12 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.041	−2.434	0.038
ARIMA model parameters 4
	Outcomes	No transformation	Constant		82.139	47.146	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−69.764	77.938	−0.895	0.394
	18 months preintervention	No transformation	Numerator	Lag 0	34.978	14.452	2.420	0.039
	18 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.041	−2.434	0.038
ARIMA model parameters 5
	Outcomes	No transformation	Constant		82.137	47.145	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−119.451	91.262	−1.309	0.223
	24 months preintervention	No transformation	Numerator	Lag 0	34.979	14.452	2.420	0.039
	24 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.041	−2.434	0.038
ARIMA model parameters 6
	Outcomes	No transformation	Constant		82.134	47.144	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−169.141	105.233	−1.607	0.142
	30 months preintervention	No transformation	Numerator	Lag 0	34.979	14.452	2.420	0.039
	30 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.041	−2.434	0.038
ARIMA model parameters 7
	Outcomes	No transformation	Constant		82.131	47.142	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−218.834	119.624	−1.829	0.101
	36 months preintervention	No transformation	Numerator	Lag 0	34.980	14.451	2.421	0.039
	36 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.041	−2.435	0.038
ARIMA model parameters 8
	Outcomes	No transformation	Constant		82.128	47.141	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−268.529	134.300	−1.999	0.077
	42 months preintervention	No transformation	Numerator	Lag 0	34.981	14.451	2.421	0.039
	42 months postintervention	No transformation	Numerator	Lag 0	−14.706	6.040	−2.435	0.038
ARIMA model parameters 9
	Outcomes	No transformation	Constant		82.125	47.140	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−318.228	149.176	−2.133	0.062
	48 months preintervention	No transformation	Numerator	Lag 0	34.982	14.450	2.421	0.039
	48 months postintervention	No transformation	Numerator	Lag 0	−14.707	6.040	−2.435	0.038
ARIMA model parameters 10
	Outcomes	No transformation	Constant		82.121	47.139	1.742	0.115
	Outcomes	No transformation	AR	Lag 1	−0.343	0.567	−0.605	0.560
	Phase	No transformation	Numerator	Lag 0	−367.929	164.198	−2.241	0.052
	54 months preintervention	No transformation	Numerator	Lag 0	34.983	14.450	2.421	0.039
	54 months postintervention	No transformation	Numerator	Lag 0	−14.707	6.040	−2.435	0.038