Experiments | Age of mouse when data were obtained | STZ intraperitoneal | Methimazole intraperitoneal | Number of mice (N) |
---|---|---|---|---|

Figure 1A | 3 weeks | N/A | N/A | N = 2 |

Figure 1B | 10 weeks | N/A | N/A | N = 2 |

Figure 1D | 10 weeks | 9 weeks | N/A | N = 61 mice |

Figure 1E | 10 weeks | 9 weeks | N/A | N = 32 mice |

Figure 1I,J | 14 weeks (d28) 23 weeks (d90) | 9 weeks (d28) 9 weeks (d90) | N/A N/A | N = 3/group( N = 2; STZ-d90) |

Figure 1L | 23 weeks | 10 weeks | N/A | N = 6/group |

Figure 2C,D,F | 11–14 weeks (d7–d28) | 9 weeks | 10 weeks | N = 3/group |

Figure 3B | 10 weeks | 7 weeks | 8 weeks | N = 6/group |

Figure 3D | 15 weeks | 9 weeks | 11 weeks | N = 6 /group |

Figure 4B | 12–14 weeks (d14–d28) | 9 weeks | 10 weeks | N = 3 (control-d14)N = 4 (STZ-d14)N = 5 (control-d28)N = 4 (STZ-d28) |

Figure 4E,F | 13–21 weeks | 6–14 weeks | 6–15 weeks (control) 7–15 weeks (STZ) | N = 6 (control)N = 4 (STZ) |

Figure 4I | 14 weeks | 9 weeks | 10 weeks | N = 4 (control)N = 5 (STZ) |

Figure 5C | 15 weeks | 9 weeks | 11 weeks | N = 7/group |

Figure 6B | 10–14 weeks (d3–d28) | 9 weeks | 10 weeks | N = 3/group exceptcontrol-d7 ( n = 2) |

Figure 6D | 11–14 weeks (d7–d28) | 9 weeks | 10 weeks | N = 3/group |

Figure 7C,D,E | 12 weeks | 9 weeks | 10 weeks | N = 3/group |

Figure 7G | N = 7–8/group | |||

Figure 7I | 12 weeks | 9 weeks | 10 weeks | N = 3/group |

Figure 8A,B | 9 weeks (uninjured) 12 weeks (d14) | N/A N/A | N/A 10 weeks (d14) | N = 3 (uninjured)N = 3 (d14) |

Figure 8E | 6 weeks | N/A | N/A | N = 4 |

Figure 8G,H,I | 10 weeks | N/A | 8 weeks | N = 3/group |

Figure 9C,F | 12 weeks | N/A | 10 weeks | N = 4 /group |