Post-KA chronic epilepsy in mice
| Administration mode | SE | Latent period | SRS | Comorbidities | References |
|---|---|---|---|---|---|
| Systemic | Starts within 15–30 min Lasts for 2–6 h 27% mortality | 2–3 d | Rarely observed Infrequent | Hyperactivity Delayed mortality | Hu et al. (1998) McKhann et al. (2003) Benkovic et al. (2004) Puttachary et al. (2015) Umpierre et al. (2016) |
| Intra-HC | Starts within 30 min Lasts for 3–12 h <5% mortality | 2–14 d | 1–2 per week Highly variable eSRS+++ | Cognitive impairment Hyperexcitability Depression (lesioned ventral hippocampus) | Bouilleret et al. (1999) Riban et al. (2002) Gouder et al. (2003) Gröticke et al. (2008) Lee et al. (2012) Zeidler et al. (2018) |
| Intra-Am | Starts within 20 min Usually terminated at 30–40 min No mortality | 3–12 d | 3 per day (±2.5) | Anxiety | Araki et al. (2002) Shinoda et al. (2004) Mouri et al. (2008) Tanaka et al. (2010) Li et al. (2012) Liu et al., 2013) |
| Supra-HC | Lasts for 2–7 h <10% mortality | 4–13 d | 2.8 per day (±3.5) | No data | Bedner et al. (2015) Jefferys et al. (2016) Pitsch et al. (2019) |
| Intranasal | Starts within 15–30 min Lasts for 1–5 h ∼6.5% mortality | 15–30 d | Reported | Increased locomotion | Chen et al. (2002) Duan et al. (2006) Zhang et al. (2008) Lu et al. (2008) Sabilallah et al. (2016) |
Am, amygdala; eSRS, electrographic SRSs; HC, hippocampus; SE, status epilepticus; SRS, spontaneous recurrent seizures