Post-KA chronic epilepsy in rats
| Administration mode | SE | Latent period | SRS | Comorbidities | References |
|---|---|---|---|---|---|
| Systemic | Starts within 2 h Lasts for 5–9 h 22% mortality | 12–36 d | 8 per day (±5.4) | Cognitive impairment Aggressiveness | Stafstrom et al. (1992) Lado (2006) Williams et al. (2009) Drexel et al. (2012) Bertoglio et al. (2017) |
| ICV | Starts within 10–30 min Lasts for 2–6 h <10% mortality | 7–14 d | 5 per day (±3.5) | Cognitive impairment | Miyamoto et al. (1997) Jing et al. (2009) Gordon et al. (2014) Song et al. (2016) Gao et al. (2019) |
| Intra-HC | Starts within 5–20 min Lasts for 3–15 h <5% mortality | 13–30 d | 8 per day (±6.3) | Cognitive impairment Perseverative behavior Hyperexcitability | Cavalheiro et al. (1982) Bragin et al. (2005) Arkhipov et al. (2008) Rattka et al., 2013) Klee et al. (2017) |
| Intra-Am | Starts within 5–30 min Lasts for 4–6 h 10% mortality | 11–24 d | 12 per day (±6.2) | No data | Ben-Ari et al. (1979) Tanaka et al. (1992) Ueda et al. (2001) Takebayashi et al. (2007) Gurbanova et al. (2008) |
Am, amygdala; HC, hippocampus; ICV, intraventricular; SE, status epilepticus; SRS, spontaneous recurrent seizures