Electrophysiological properties of PV interneurons recorded from heterozygous (Scn1aKT/+) and control (Scn1a+/+) mice, respectively
| Properties | Scn1a+/+ | Scn1aKT/+ | p value |
|---|---|---|---|
| Cells # (animals #) | 14 (5) | 9 (3) | |
| Capacitance (pF) | 45.58 ± 9.16 | 60.0 ± 18.69 | 0.402 |
| Input resistance (MΩ) | 111.79 ± 21.86 | 74.83 ± 8.94 | 0.477 |
| Resting potential (mV) | −65.14 ± 0.61 | −63.88 ± 0.82 | 0.227 |
| AP threshold (mV) | −41.79 ± 0.77 | −37.70 ± 1.28** | 0.0069 |
| AP amplitude (mV) | 61.24 ± 1.88 | 48.26 ± 4.01** | 0.005 |
| AP half-width (ms) | 0.285 ± 0.01 | 0.332 ± 0.01* | 0.031 |
| Spike Frequency Adaptation (ISI1/ISIn) | 0.820 ± 0.11 | 0.883 ± 0.19 | 0.926 |
Statistical comparisons were made with unpaired Mann–Whitney test except resting membrane potential that was compared with Student’s unpaired t test; *p < 0.05 and **p < 0.01.