Table 1

Summary of the properties of the motoneurons, broken down by age range

P30–P60P60–P90P90–P120
WT
(N = 19)
SOD1
(N = 15)
Hedges’ gWT
(N = 16)
SOD1
(N = 24)
Hedges’ gWT
(N = 15)
SOD1
(N = 14)
Hedges’ g
Input
conductance
0.42 ± 0.16 μS
[0.35–0.49]
0.72 ± 0.18 μS
[0.64–0.82]
1.73
[0.93–2.40]
(p = 2.2e
−05****)
0.46 ± 0.16 μS
[0.39–0.54]
0.42 ± 0.15 μS
[0.36–0.48]
−0.28
[−0.96–0.39]
(p = 0.39)
0.60 ± 0.15 μS
[0.53–0.67]
0.33 ± 0.13 μS
[0.26–0.39]
−1.85
[−2.57–−1.17]
(p = 2.1e
−05****)
PIC
amplitude
2.30 ± 2.17 nA
[1.52–3.45]
6.73 ± 3.28 nA
[5.18–8.51]
1.59
[0.62–2.48]
(p = 0.00016***)
2.47 ± 1.69 nA
[1.81–3.51]
2.75 ± 2.40 nA
[1.97–3.89]
0.12
[−0.53–0.67]
(p = 0.67)
4.12 ± 3.69 nA
[2.67–6.40]
1.90 ± 1.78 nA
[1.24–3.19]
−0.74
[−1.27–0.00]
(p = 0.05)
PIC
amplitude
(down ramp)
2.65 ± 2.60 nA
[1.76–4.16]
5.55 ± 3.48 nA
[4.01–7.45]
0.94
[0.15–1.70]
(p = 0.013*)
2.29 ± 2.30 nA
[1.52–4.01]
2.87 ± 2.22 nA
[2.12–3.87]
0.25
[−0.50–0.82]
(p = 0.44)
4.43 ± 3.10 nA
[3.03–6.09]
2.25 ± 1.98 nA
[1.48–3.56]
−0.81
[−1.49–−0.03]
(p = 0.032*)
Current at
transition
SPR/PR
5.93 ± 3.24 nA
[4.37–8.51]
8.01 ± 2.67 nA
[6.54–9.24]
0.69
[−0.48–1.68]
(p = 0.13)
6.28 ± 3.92 nA
[4.32–9.67]
5.23 ± 3.30 nA
[3.99–7.23]
−0.29
[−1.34–0.48]
(p = 0.53)
5.90 ± 2.70 nA
[4.24–7.38]
2.70 ± 2.34 nA
[1.18–3.76]
−1.23
[−2.07–−0.35]
(p = 0.0081**)
Recruitment
current
4.73 ± 3.14 nA
[3.50–6.23]
6.21 ± 2.51 nA
[4.77–7.27]
0.50
[−0.25–1.26]
(p = 0.14)
5.28 ± 2.64 nA
[4.19–6.79]
4.53 ± 3.38 nA
[3.35–6.35]
−0.24
[−0.94–0.43]
(p = 0.46)
5.43 ± 3.07 nA
[4.07–7.16]
2.19 ± 1.56 nA
[1.59–3.32]
−1.26
[−1.96–−0.52]
(p = 0.0017**)
Current
at de-
recruitment
5.92 ± 3.76 nA
[4.38–7.65]
7.64 ± 3.31 nA
[5.91–9.24]
0.47
[−0.24–1.19]
(p = 0.17)
6.54 ± 4.07 nA
[4.69–9.12]
5.01 ± 4.05 nA
[3.54–7.04]
−0.37
[−1.16–0.33]
(p = 0.31)
5.64 ± 2.95 nA
[4.03–7.22]
2.59 ± 1.58 nA
[1.93–3.64]
−1.26
[−2.23–−0.37]
(p = 0.0056**)
Frequency at
transition
SPR/PR
54.30 ± 17.35 Hz
[45.49–66.17]
57.90 ± 17.06 Hz
[49.74–66.74]
0.20
[−0.65–1.04]
(p = 0.62)
53.55 ± 13.32 Hz
[44.57–62.21]
43.75 ± 13.55 Hz
[36.99–49.60]
−0.70
[−1.52–0.09]
(p = 0.11)
51.58 ± 15.41 Hz
[41.70–59.94]
42.44 ± 11.34 Hz
[36.74–48.89]
−0.67
[−1.58–0.23]
(p = 0.13)
Normalized PIC
amplitude
(down ramp)
6.72 ± 5.77
nA/μS
[4.50–9.57]
7.85 ± 4.85
nA/μS
[5.49–10.58]
0.20
[−0.48–0.96]
(p = 0.56)
5.05 ± 4.43
nA/μS
[3.38–7.73]
6.81 ± 5.14 nA/μS
[5.24–9.34]
0.35
[−0.35–0.89]
(p = 0.26)
7.77 ± 5.24 nA/μS
[5.46–10.56]
6.72 ± 4.91
nA/μS
[4.77–9.82]
−0.20
[−0.92–0.60]
(p = 0.58)
ΔI (current
at de-
recruitment−
recruitment)
1.20 ± 1.20 nA
[0.69–1.74]
1.45 ± 1.25 nA
[0.89–2.17]
0.20
[−0.49–0.87]
(p = 0.57)
1.47 ± 1.83 nA
[0.57–2.52]
0.42 ± 1.10 nA
[−0.01–0.94]
−0.72
[−1.57–0.05]
(p = 0.093)
0.98 ± 1.32 nA
[0.38–1.78]
0.39 ± 0.63 nA
[0.05–0.71]
−0.55
[−1.28–0.27]
(p = 0.18)
Voltage threshold
(relative
to RMP)
17.03 ± 6.37 mV
[14.16–19.76]
18.09 ± 5.21 mV
[15.10–20.44]
0.17
[−0.53–0.86]
(p = 0.61)
15.59 ± 5.54 mV
[13.26–18.55]
19.26 ± 6.29 mV
[16.80–22.24]
0.60
[−0.13–1.26]
(p = 0.072)
17.10 ± 5.54 mV
[14.32–19.66]
13.79 ± 3.62 mV
[12.09–15.77]
−0.67
[−1.44–0.15]
(p = 0.071)
ΔF (frequency
at de-
recruitment−
recruitment)
1.79 ± 13.96 Hz
[−5.29–7.01]
3.77 ± 11.06 Hz
[−1.51–9.55]
0.15
[−0.56–0.80]
(p = 0.65)
6.53 ± 17.29 Hz
[0.25–21.46]
1.93 ± 8.73 Hz
[−1.51–6.16]
−0.36
[−1.12–0.37]
(p = 0.4)
−0.85 ± 7.97 Hz
[−4.64–4.12]
0.75 ± 7.97 Hz
[−3.66–4.64]
0.19
[−0.66–1.04]
(p = 0.62)
PIC peak
voltage
(relative
to RMP)
18.32 ± 7.08 mV
[15.26–21.42]
19.13 ± 8.15 mV
[14.28–22.51]
0.10
[−0.61–0.82]
(p = 0.76)
18.09 ± 7.71 mV
[15.11–22.59]
21.18 ± 5.82 mV
[19.14–23.99]
0.45
[−0.34–1.10]
(p = 0.19)
16.37 ± 8.32 mV
[12.41–20.31]
15.60 ± 5.86 mV
[12.55–18.63]
−0.10
[−0.87–0.66]
(p = 0.78)
F-I gain
(PR, descending
ramp)
19.21 ± 10.07
Hz/nA
[15.19–29.17]
17.23 ± 5.15
Hz/nA
[14.91–20.03]
−0.25
[−1.15–0.58]
(p = 0.58)
33.93 ± 35.75 Hz/nA
[18.24–75.19]
15.25 ± 8.95
Hz/nA
[11.99–21.30]
−0.88
[−1.69–0.11]
(p = 0.22)
15.15 ± 7.14
Hz/nA
[11.73–20.87]
20.05 ± 11.30
Hz/nA
[15.50–28.05]
0.48
[−0.48–1.07]
(p = 0.23)
F-I gain
(PR, ascending
ramp)
9.30 ± 3.58
Hz/nA
[7.08–11.31]
8.30 ± 3.37
Hz/nA
[6.42–9.86]
−0.28
[−1.09–0.63]
(p = 0.5)
12.18 ± 7.30
Hz/nA
[8.81–19.47]
10.28 ± 6.43
Hz/nA
[8.15–15.26]
−0.27
[−1.23–0.53]
(p = 0.54)
8.01 ± 3.16 Hz/nA
[6.33–10.08]
10.84 ± 9.13
Hz/nA
[7.69–19.20]
0.38
[−0.41–0.94]
(p = 0.31)
PIC onset voltage
(relative to RMP)
4.36 ± 5.66 mV
[1.69–6.68]
2.05 ± 5.38 mV
[−1.02–4.23]
−0.41
[−1.05–0.28]
(p = 0.23)
1.76 ± 5.75 mV
[−0.85–4.65]
6.12 ± 5.54 mV
[3.80–8.38]
0.76
[0.01–1.40]
(p = 0.025*)
1.57 ± 5.10 mV
[−0.86–4.11]
0.92 ± 5.94 mV
[−1.76–4.48]
−0.11
[−0.93–0.64]
(p = 0.76)
Resting membrane
potential
−62.38 ± 5.52 mV
[−64.71–−59.91]
−71.45 ± 8.78 mV
[−75.13–−66.37]
−1.24
[−2.19–−0.28]
(p = 0.002**)
−60.98 ± 5.35 mV
[−63.81–−58.71]
−66.18 ± 5.63 mV
[−68.56–−63.88]
−0.92
[−1.54–−0.19]
(p = 0.0067**)
−64.71 ± 7.42 mV
[−68.61–−61.39]
−61.99 ± 5.43 mV
[−64.41–−58.61]
0.40
[−0.32–1.10]
(p = 0.27)
Voltage threshold
for spiking
−45.35 ± 5.48 mV
[−47.79–−43.03]
−54.86 ± 5.15 mV
[−57.21–−52.17]
−1.74
[−2.53–−0.84]
(p = 1.9e
−05****)
−45.39 ± 7.04 mV
[−49.10–−42.26]
−47.53 ± 5.85 mV
[−49.76–−44.73]
−0.33
[−1.04–0.38]
(p = 0.34)
−47.61 ± 5.00 mV
[−49.94–−45.17]
−48.20 ± 5.41 mV
[−50.94–−45.31]
−0.11
[−0.85–0.63]
(p = 0.77)
PIC peak voltage−43.83 ± 4.79 mV
[−45.74–−41.49]
−52.32 ± 4.20 mV
[−54.10–−50.00]
−1.83
[−2.60–−1.03]
(p = 4.8e
−06****)
−42.89 ± 6.94 mV
[−45.81–−39.26]
−44.88 ± 5.24 mV
[−46.93–−42.88]
−0.33
[−0.97–0.33]
(p = 0.34)
−48.34 ± 5.89 mV
[−50.89–−45.11]
−46.24 ± 6.27 mV
[−49.56–−43.26]
0.34
[−0.43–1.15]
(p = 0.36)
PIC onset voltage−58.03 ± 6.35 mV
[−60.91–−55.34]
−69.41 ± 5.71 mV
[−71.66–−66.01]
−1.83
[−2.69–−0.81]
(p = 5.1e−06****)
−59.22 ± 4.88 mV
[−61.96–−57.18]
−59.66 ± 6.39 mV
[−61.98–−56.91]
−0.07
[−0.70–0.54]
(p = 0.81)
−63.15 ± 6.31 mV
[−65.99–−59.85]
−60.12 ± 7.25 mV
[−63.92–−56.48]
0.43
[−0.35–1.17]
(p = 0.24)
PIC end
voltage
−58.67 ± 6.87 mV
[−61.68–−55.65]
−71.37 ± 6.36 mV
[−73.99–−67.60]
−1.86
[−2.69–−0.80]
(p = 4.1e−06****)
−60.48 ± 4.90 mV
[−63.57–−58.66]
−61.80 ± 7.27 mV
[−64.75–−58.95]
−0.20
[−0.77–0.42]
(p = 0.5)
−65.00 ± 5.70 mV
[−67.79–−62.19]
−61.30 ± 8.12 mV
[−65.34–−57.16]
0.52
[−0.28–1.27]
(p = 0.17)
PIC peak
voltage
(down ramp)
−43.73 ± 4.89 mV
[−45.62–−41.28]
−53.63 ± 4.90 mV
[−55.76–−50.95]
−1.97
[−2.78–−1.17]
(p = 2.1e−06****)
−42.49 ± 8.15 mV
[−45.71–−37.94]
−45.85 ± 6.11 mV
[−48.41–−43.56]
−0.47
[−1.08–0.16]
(p = 0.17)
−48.14 ± 5.25 mV
[−50.45–−45.05]
−45.98 ± 6.26 mV
[−49.54–−43.13]
0.37
[−0.41–1.20]
(p = 0.32)
  • The table shows the various properties that were measured in each motoneuron. The rows are sorted in descending order of effect size at P30–P60. WT and mSOD1 columns show mean values ± SD, with the 95%CI around the mean below. The Hedges’ g column shows the effect size and its 95%CI below.