Table 2

Intersex comparison of Disc1 svΔ2 neural microstructure

DTI measure	Hemi	ROI	Mean (±SEM)		p value
DTI measure	Hemi	ROI	Disc1 svΔ2 female	Disc1 svΔ2 male
FA	Right	HC	0.22138 (±0.00475)	0.23499 (±0.00313)	<0.05^a^,b
		EC	0.41625 (±0.00615)	0.44551 (±0.00385)	<0.01^a^,b
		BG	0.16134 (±0.00511)	0.17224 (±0.00498)	0.079
		IC	0.35081 (±0.00597)	0.37733 (±0.00336)	<0.01^a^,b
		NC	0.18757 (±0.00216)	0.20222 (±0.00126)	<0.01^a^,b
		CC	0.55118 (±0.01252)	0.60223 (±0.00361)	<0.01^a^,b
	Left	HC	0.21364 (±0.00605)	0.23356 (±0.00281)	<0.01^a^,b
		EC	0.40232 (±0.00569)	0.42855 (±0.00279)	<0.01^a^,b
		BG	0.16496 (±0.00326)	0.18700 (±0.00259)	<0.01^a^,b
		IC	0.62077 (±0.00764)	0.62837 (±0.00843)	0.260
		NC	0.18935 (±0.00219)	0.20187 (±0.00276)	<0.01^a^,b
		CC	0.55733 (±0.01176)	0.59938 (±0.00633)	<0.01^a^,b
MD	Right	HC	0.39116 (±0.00724)	0.39350 (±0.00594)	0.404
		EC	0.30833 (±0.01012)	0.30550 (±0.00354)	0.399
		BG	0.36366 (±0.00762)	0.37150 (±0.01014)	0.275
		IC	0.32733 (±0.0116)	0.33150 (±0.00744)	0.384
		NC	0.36583 (±0.00438)	0.37683 (±0.00582)	0.081
		CC	0.26500 (±0.01066)	0.25233 (±0.00352)	0.143
	Left	HC	0.38983 (±0.00517)	0.39716 (±0.00683)	0.206
		EC	0.31033 (±0.00486)	0.30800 (±0.00508)	0.374
		BG	0.36433 (±0.00624)	0.37216 (±0.01100)	0.275
		IC	0.27216 (±0.00855)	0.27850 (±0.00407)	0.259
		NC	0.36900 (±0.00405)	0.38183 (±0.00611)	0.055
		CC	0.25333 (±0.0093)	0.23950 (±0.00313)	0.095
NDI	Right	HC	0.28407 (±0.00956)	0.26707 (±0.00871)	0.109
		EC	0.46351 (±0.00943)	0.45174 (±0.00608)	0.160
		BG	0.31111 (±0.00865)	0.29408 (±0.01434)	0.167
		IC	0.41161 (±0.01145)	0.4146 (±0.01761)	0.445
		NC	0.32010 (±0.00613)	0.30277 (±0.00925)	0.075
		CC	0.53613 (±0.00934)	0.54253 (±0.00564)	0.285
	Left	HC	0.28127 (±0.00719)	0.26581 (±0.00928)	0.109
		EC	0.44984 (±0.00804)	0.45002 (±0.00541)	0.493
		BG	0.30895 (±0.00511)	0.29646 (±0.01709)	0.250
		IC	0.57928 (±0.01304)	0.57002 (±0.01176)	0.305
		NC	0.31719 (±0.00547)	0.30039 (±0.00861)	0.065
		CC	0.55257 (±0.01351)	0.55457 (±0.00409)	0.445
ODI	Right	HC	0.22146 (±0.00522)	0.19927 (±0.00745)	<0.05^a^,b
		EC	0.16932 (±0.00527)	0.15200 (±0.00203)	<0.01^a^,b
		BG	0.33371 (±0.01499)	0.30247 (±0.01745)	0.102
		IC	0.20551 (±0.00673)	0.18788 (±0.00966)	0.083
		NC	0.30206 (±0.0077)	0.27409 (±0.00876)	<0.05^a^,b
		CC	0.11905 (±0.01174)	0.10064 (±0.00210)	0.077
	Left	HC	0.23155 (±0.00736)	0.19509 (±0.00768)	<0.01^a^,b
		EC	0.17760 (±0.00740)	0.16079 (±0.00440)	<0.05^a
		BG	0.32845 (±0.01229)	0.28399 (±0.01504)	<0.05^a
		IC	0.08432 (±0.00457)	0.08015 (±0.00521)	0.280
		NC	0.30203 (±0.00728)	0.27898 (±0.01100)	0.056
		CC	0.12966 (±0.00821)	0.11224 (±0.00687)	0.067

All values are mean ± SEM. Units of measure for FA, MD, NDI, and ODI are 10³ mm²/s. ROIs correspond to ROIs derived from the P72 UNC Atlas. Diffusion measure abbreviations: Hemi = hemisphere; FA = fractional anisotropy; MD = mean diffusivity, NDI = neurite density index; ODI = orientation dispersion index. ROI abbreviations: HC = hippocampus; EC = external capsule; BG = basal ganglia; IC = internal capsule; NC = neocortex; CC = corpus callosum. For all sample groups, n = 6.
↵a Statistically significant.
b Statistically significant after controlling the FDR with the Benjamini–Hochberg procedure (FDR = 0.05).