Table 2

Effect sizes for Figure 4E

Dendritic length (μm)	Conductance	gAMPA	Mean “total” CV	SD	Effect size (d)	gAMPA	Mean “total” CV	SD	Effect size (d)
200	AMPA-only ●	500	0.317	0.048
	AMPA + fast NMDA	400 ●	0.326	0.023	0.325	250 ●	0.358	0.025	1.469
	AMPA + slow AMPA	400 ●	0.313	0.022	–0.169	250 ●	0.306	0.017	–0.394
	AMPA+NMDA	400 ●	0.319	0.020	0.057	250 ●	0.325	0.017	0.263
400	AMPA-only ●	500	0.365	0.280
	AMPA + fast NMDA	400 ●	0.367	0.034	0.060	250 ●	0.392	0.027	0.721
	AMPA + slow AMPA	400 ●	0.363	0.024	–0.071	250 ●	0.352	0.014	–0.371
	AMPA+NMDA	400 ●	0.357	0.024	–0.223	250 ●	0.358	0.013	–0.205
600	AMPA-only ●	500	0.429	0.038
	AMPA + fast NMDA	400 ●	0.394	0.026	–0.940	250 ●	0.406	0.018	–0.623
	AMPA + slow AMPA	400 ●	0.420	0.027	–0.253	250 ●	0.409	0.016	–0.546
	AMPA+NMDA	400 ●	0.370	0.018	–1.578	250 ●	0.375	0.010	–1.450
200 (on large neuron)	AMPA-only ●	500	0.414	0.019
	AMPA + fast NMDA	400 ●	0.390	0.018	–1.308	250 ●	0.405	0.021	–0.476
	AMPA + slow AMPA	400 ●	0.410	0.016	–0.222	250 ●	0.402	0.010	–0.666
	AMPA+NMDA	400 ●	0.360	0.013	–2.886	250 ●	0.374	0.007	–2.140
800	AMPA-only ●	500	0.625	0.046
	AMPA + fast NMDA	400 ●	0.434	0.035	–4.131	250 ●	0.415	0.027	–4.535
	AMPA + slow AMPA	400 ●	0.612	0.037	–0.283	250 ●	0.601	0.020	–0.520
	AMPA+NMDA	400 ●	0.369	0.023	–5.537	250 ●	0.389	0.010	–5.104
1000	AMPA-only ●	500	2.071	0.076
	AMPA + fast NMDA	400 ●	0.630	0.041	–18.964	250 ●	0.495	0.036	–20.737
	AMPA + slow AMPA	400 ●	2.147	0.065	1.002	250 ●	2.337	0.058	3.493
	AMPA+NMDA	400 ●	0.847	0.077	–16.111	250 ●	0.405	0.010	–21.928

Listed are the mean “total” CVs, SDs, and effect sizes (relative to AMPA-only synapses) for synaptic thresholds calculated across all dendritic locations and all RMPs averaged from 10 patterns of synaptic input for each type of synaptic conductance (color coded to data in Fig. 4E). Effect sizes (d) indicate the normalized mean difference in CV relative to the CV for the 500 pS AMPA-only conductance, in units of sAMPA-only (see Materials and Methods). Sign indicates the direction of change [larger (+) or smaller (–) mean CVs than AMPA-only inputs]. Light shading (blue = smaller CVs, red = larger CVs) identifies manipulations generating mean changes in CV >0.5 SD, while darker shadings indicate mean changes >1.0 SD of the AMPA-only result. Note that AMPA+NMDA conductances generated consistently larger reductions in CV relative to manipulations that provided voltage dependence or slower kinetics alone. The large neuron with a 200-μm dendrite (tested) included three additional 600-μm dendrites (as in Fig. 3A).