Table 1

Model parameters

Neuron morphologyCompartmentDimensions (l × w)Number of
segments
Active properties (max. conductance)
Ball-and-stick*Soma20 × 10 μm3Na+: 100 pS/μm2
K+: 100 pS/μm2
Dendrite200–1000 μm, tapering
from 5 to 1 μm
1 per μmTypically passive. Figure 3C: Na+ and
K+ with linear decrease (100–10 pS/μm2).
CA3* and dentate granule
neurons
SomaAs reconstructed3Na+: 100 pS/μm2
K+: 100 pS/μm2
DendritesAs reconstructed1 per μmPassive
All morphologiesSpinesNeck: 1 × ∼0.05 μm
Head: 0.5 × 0.5 μm
1
1
As in parent dendritic compartment
AIS40 μm, tapering from 2 to
0.5 μm
40Na+: 100 pS/μm2 (1st 5 μm) or 8000 pS/μm2
K+: 100pS/μm2 (1st 5 μm) or 2000 pS/μm2
Axon2000 × 0.5 μm201Na+: 300 pS/μm2
K+: 60 pS/μm2
  • Listed are the parameters for model neurons used in this study. General model parameters: RM = 15 kΩ•cm2; CM = 1 μF/cm2; Ri = 100 Ω•cm; Epas = −55 to −85 mV, as indicated in text; time steps, 10 or 25 μs; nominal temperature 37°C. *The ball-and-stick model in Figure 1 and the CA3 neuron in Figure 8 are purely passive (including in somata and axons).