Electrophysiological parameters measured for DNs at time 0 for all experimental treatments
| Vehicle/control | α-Syn aggregates | α-Syn monomers | Glib + vehicle | Glib + α-syn aggregates | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Mean | SEM | SD | Mean | SEM | SD | Mean | SEM | SD | Mean | SEM | SD | Mean | SEM | SD |
| RMP (mV) | −55.8 | ±1.2 | ±3.79 | −55.4 | ±1.23 | ±4.10 | −56.8 | ±1.30 | ±3.18 | −53.2 | ±2.14 | ±5.24 | −60.4 | ±1.82 | ±4.08 |
| R in (MΩ) | 338 | ±17.6 | ±55.8 | 312 | ±17.1 | ±56.8 | 359 | ±42.2 | ±103.3 | 386 | ±25.2 | ±61.7 | 294 | ±41.9 | ±93.6 |
| Firing rate (Hz) | 1.63 | ±0.39 | ±0.12 | 2.51 | ±1.57 | ±0.47 | 2.38 | ±1.14 | ±0.46 | 2.27 | ±1.15 | ±0.47 | 2.04 | ±1.29 | ±0.52 |
| C (pF) | 88.8 | ±5.74 | ±14.1 | 107.8 | ±5.84 | ±14.3 | 80.73 | ±15.1 | ±37.0 | 81.16 | ±8.54 | ±20.9 | 117 | ±22.3 | ±54.7 |
| g (nS) | 2.29 | ±0.2 | ±0.49 | 2.78 | ±0.2 | ±0.49 | 1.99 | ±0.3 | ±0.73 | 2.39 | ±0.29 | ±0.71 | 3.67 | ±0.55 | ±1.35 |