The effect of topical LY354740 application on RLFs’ peak firing rates, slopes, and thresholds
| Term | Statistic | p value |
|---|---|---|
| Peak firing rate | ||
| Overall ANOVA | ||
| Drug | F(1,253) = 80.8 | <0.0001 |
| Cluster | F(2,28) = 2.8 | 0.07 |
| Drug-cluster interaction | F(2,253) = 44.3 | <0.0001 |
| Pairwise comparisons with clusters | ||
| Cluster #1: pre-drug–post-drug | t(253) = 10.7 | <0.0001 |
| Cluster #2: pre-drug–post-drug | t(253) = 5.9 | <0.0001 |
| Cluster #3: pre-drug–post-drug | t(253) = −1.8 | 0.07 |
| Slope | ||
| Overall ANOVA | ||
| Drug | F(1,253) = 13.9 | <0.001 |
| Cluster | F(2,28) = 0.9 | 0.4 |
| Drug-cluster interaction | F(2,253) = 5.6 | <0.01 |
| Pairwise comparisons with clusters | ||
| Cluster #1: pre-drug–post-drug | t(253) = 2.5 | <0.05 |
| Cluster #2: pre-drug–post-drug | t(253) = 4.3 | <0.0001 |
| Cluster #3: pre-drug–post-drug | t(253) = −0.4 | 0.7 |
| Threshold | ||
| Overall ANOVA | ||
| Drug | F(1,253) = 47.0 | <0.0001 |
| Cluster | F(2,28) = 0.8 | 0.4 |
| Drug-cluster interaction | F(2,253) = 11.1 | <0.0001 |
| Pairwise comparisons with clusters | ||
| Cluster #1: pre-drug–post-drug | t(253) = −6.6 | <0.0001 |
| Cluster #2: pre-drug–post-drug | t(253) = −4.4 | <0.0001 |
| Cluster #3: pre-drug–post-drug | t(253) = −0.5 | 0.6 |
The drug had a significant effect on all three dependent variables in clusters #1 and #2, but not in cluster #3, neurons. Significant p values are highlighted in bold.