Table 1

Top GO groups enriched for differential expression in areas of AD-associated hypometabolism in brain 10‚ÄČ021/H0351.2002

NameGenesIDAUCp valueFDR
SRP-dependent cotranslational protein targeting to membrane87GO:00066140.8741.35E-29
Cotranslational protein targeting to membrane90GO:00066130.8652.07E-29
Protein targeting to ER92GO:00450470.8472.86E-27
Cytosolic ribosome87GO:00226260.8563.45E-27
Establishment of protein localization to endoplasmic reticulum96GO:00725990.8281.66E-25
Structural constituent of ribosome107GO:00037350.7941.05E-22
Ribosomal subunit158GO:00443910.7371.01E-21
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay104GO:00001840.7832.07E-20
Protein localization to endoplasmic reticulum109GO:00709720.7659.44E-19
Cytosolic large ribosomal subunit47GO:00226250.8946.73E-18
microtubule organizing center part145GO:00444500.3950.00244
DNA-dependent ATPase activity59GO:00080940.330.00145
HOPS complex13GO:00308970.1370.00135
ATPase activity, coupled186GO:00426230.3960.00026
tRNA aminoacylation for protein translation40GO:00064180.2689.84E-05
Amino acid activation43GO:00430380.2758.24E-05
Aminoacyl-tRNA ligase activity33GO:00048120.2438.24E-05
Cullin-RING ubiquitin ligase complex111GO:00314610.3553.84E-05
tRNA aminoacylation42GO:00430390.2591.91E-05
Ubiquitin ligase complex195GO:00001510.3687.35E-08