Table 2

Quantitative analysis of axonal KIF1A-S402A and KIF1A-S402E transport in tau+/+ neurons

Traffic values
S402A + ABO1.23 ± 0.10****####$$1.35 ± 0.12****### 1.13 ± 0.11### S402E2.03 ± 0.102.23 ± 0.121.51 ± 0.12 Run length (μm) WT9.14 ± 1.0210.74 ± 1.365.64 ± 0.57 WT + ABO6.26 ± 0.62* 6.62 ± 0.68* 5.64 ± 0.89 S402A7.34 ± 0.909.03 ± 1.425.31 ± 0.39 S402A + ABO4.77 ± 0.29*** 4.93 ± 0.42***# 4.53 ± 0.25 S402E9.09 ± 0.9010.46 ± 1.085.31 ± 0.54 • WT: n = 16 kymographs (16 cells, 789 puncta). • S402A: n = 16 kymographs (16 cells, 829 puncta). • WT + ABO: n = 18 kymographs (18 cells, 381 puncta). • S402A + ABO: n = 18 kymographs (18 cells, 430 puncta). • S402E: n = 16 kymographs (16 cells, 743 puncta). • *p < 0.05, when compared with WT. • **p < 0.01, when compared with WT. • ***p < 0.001, when compared with WT. • ****p < 0.0001, when compared with WT. • #p < 0.05, when compared with S402A. • ##p < 0.01, when compared with S402A. • ###p < 0.001, when compared with S402A. • ####p < 0.0001, when compared with S402A. • p < 0.05, when comparing AβO-treated conditions (significance denoted in S402 + AβO condition). •$$p < 0.01, when comparing AβO-treated conditions (significance denoted in S402 + AβO condition).
• $$p < 0.001, when comparing AβO-treated conditions (significance denoted in S402 + AβO condition). •$$p < 0.0001, when comparing AβO-treated conditions (significance denoted in S402 + AβO condition).