Table 1

Quantitative analysis of axonal KIF1A-GFP transport in tau+/+ and tau−/− neurons.

Traffic values
All EventsAnterogradeRetrograde
Flux (min–1)   
 tau+/+ vehicle10.46 ± 0.487.03 ± 0.783.35 ± 0.38
 tau+/+ AβOs5.83 ± 0.24**** 2.71 ± 0.65**** 3.12 ± 0.35
 tau+/+ VII + AβOs7.56 ± 0.53*# 4.19 ± 0.35# 3.37 ± 0.40
 tau−/− vehicle10.74 ± 0.707.38 ± 0.353.35 ± 0.33
 tau−/− AβOs5.77 ± 0.43**** 3.11 ± 0.25**** 2.66 ± 0.32
 tau−/− VII + AβOs10.38 ± 1.01#### 7.42 ± 0.76#### 2.95 ± 0.38
Velocity (μm/s)   
 tau+/+ vehicle1.68 ± 0.122.04 ± 0.161.33 ± 0.12
 tau+/+ AβOs1.63 ± 0.121.72 ± 0.171.31 ± 0.16
 tau+/+ VII + AβOs1.75 ± 0.081.48 ± 0.181.47 ± 0.09
 tau−/− vehicle1.93 ± 0.072.28 ± 0.141.55 ± 0.07
 tau−/− AβOs1.41 ± 0.18* 1.54 ± 0.19* 1.30 ± 0.19
 tau−/− VII + AβOs1.98 ± 0.11# 2.35 ± 0.16# 1.54 ± 0.12
Run length (μm)   
 tau+/+ vehicle18.85 ± 1.0926.02 ± 2.0212.09 ± 1.30
 tau+/+ AβOs17.26 ± 1.6519.74 ± 2.8313.37 ± 2.00
 tau+/+ VII + AβOs17.48 ± 0.9423.05 ± 1.6710.96 ± 0.76
 tau−/− vehicle20.39 ± 1.0527.32 ± 2.1313.75 ± 1.21
 tau−/− AβOs11.27 ± 0.88**** 13.38 ± 1.11*** 9.82 ± 0.91
 tau−/− VII + AβOs20.79 ± 2.01#### 29.38 ± 3.77### 12.64 ± 0.72
  • tau+/+ vehicle: n = 24 kymographs (24 cells, 893 puncta).

  • tau−/− vehicle: n = 27 kymographs (27 cells, 1014 puncta).

  • tau+/+ AβO: n = 18 kymographs (19 cells, 432 puncta).

  • tau−/− AβO: n = 18 kymographs (18 cells, 578 puncta).

  • tau+/+ VIII + AβO: n = 18 kymographs (18 cells, 643 puncta).

  • tau−/− VIII + AβO: n = 17 kymographs (17 cells, 638 puncta).

  • *p < 0.05, when compared with vehicle.

  • **p < 0.01, when compared with vehicle.

  • ***p < 0.001, when compared with vehicle.

  • ****p < 0.0001, when compared with vehicle.

  • #p < 0.05, when compared with AβOs.

  • ##p < 0.01, when compared with AβOs.

  • ###p < 0.001, when compared with AβOs.

  • ####p < 0.0001, when compared with AβOs.