Table 5

Statistical analyses of the IVSA profile in all lines ( Fig. 4)

ItemFigureExperimentStatistical testEffect or interactionMain effectflMORD1flMORD2flMORA2aflMORChATflMOR
a 3A Remifentanil acquisitionLMMAL day effectp < 0.0001, χ2 = 21.017n = 15n = 12n = 10n = 12n = 12
b 3C Remifentanil acquisitionLMMRNFS earned day effectp < 0.0001, χ2 = 19.132
c 3D Remifentanil acquisitionLMMPercent AL presses day effectp < 0.01, χ2 = 9.730
d 3E Oxycodone maintenanceLMMAL presses × Treatment Oxycodone vs. Salinep < 0.001, χ2 = 10.926p < 0.001, χ2 = 11.601, n = 14p < 0.01, χ2 = 6.764, n = 9p < 0.001, χ2 = 12.806, n = 9p < 0.01, χ2 = 10.545, n = 8p < 0.001, χ2 = 13.68, n = 7
e 3G Oxycodone maintenanceLMMRNFS × treatment Oxycodone vs. Salinep < 0.0001, χ2 = 16.051p < 0.001, χ2 = 11.435p < 0.01, χ2 = 8.434p < 0.01, χ2 = 9.339p < 0.001, χ2 = 10.981p < 0.001, χ2 = 14.648
f 3G Oxycodone maintenanceLMMPercent AL presses treatment × day oxycodone vs salinep < 0.0001, χ2 = 34.81p < 0.0001, χ2 = 15.957p < 0.0001, χ2 = 20.334p < 0.01, χ2 = 7.918p < 0.0001, χ2 = 16.952p < 0.0001, χ2 = 19.941
g 3E Extinction; transitionLMMAL presses treatment × day oxycodone vs. salinep < 0.01, χ2 = 8.296
h 3G Extinction; transitionLMMRNFS treatment × day oxycodone vs. salinep < 0.01, χ2 = 7.047
i 3E Extinction; transitionLMMAL presses
day effect within oxycodone treated
p < 0.0001, χ2 = 29.255
j 3F Extinction; transitionLMMIAL presses
day effect within oxycodone treated
p < 0.01, χ2 = 9.396
k 3G Extinction; transitionLMMRNFS day effect within oxycodone treatedp < 0.0001, χ2 = 25.725
l 3G ExtinctionLMMAL presses × genotype within oxycodone treatedp = 0.050, χ2 = 9.480N.A.N.S.N.S.p = 0.043N.S.
m 3G ExtinctionLMMIAL presses × genotype within oxycodone treatedp = 0.057, χ2 = 9.148N.A.N.S.N.S.p = 0.025N.S.
n 3G ExtinctionLMMRNFS earned × genotype within oxycodone treatedp = 0.018, χ2 = 11.934N.A.N.S.N.S.p = 0.031p = 0.007
o 3G ExtinctionLMMRNFS earned
day effect
p < 0.001, χ2 = 12.979p < 0.001,
t(50) = –4.124
p < 0.001,
t(53) = –3.964
p < 0.001,
t(55) = –3.946
p < 0.001,
t(55) = –3.135
p < 0.001,
t(56) = –2.726
p 3I Last day AL oxycodoneTwo-way ANOVAGenotype × timeF(480,5160) = 0.45, p > 0.99
q 3L Last day oxycodone RNFSTwo-way ANOVAGenotype × timeF(480,4920) = 0.2, p > 0.99
r 3J First day extinction ALTwo-way ANOVAGenotype × timeF(480,4920) = 1.44, p < 0.0001Reference genotypeN.S.N.S.p < 0.05N.S.
s 3M First day extinction RNFSTwo-way ANOVAGenotype × timeF(480,4800) = 1.66, p < 0.0001Reference genotypeN.S.N.S.p < 0.05p < 0.05
t 3J Third day extinction ALTwo-way ANOVAGenotype × timeF(480,5160) = 0.42, p > 0.99Reference genotypeN.S.N.S.N.S.N.S.
u 3M Third day extinction RNFSTwo-way ANOVAGenotype × timeF(480,5280) = 2.02, p < 0.0001Reference genotypeN.S.N.S.N.S.p < 0.05 and p < 0.01
  • N.S.: not significant, N.A: not applicable.