Table 1

Experiment 1 statistical analysis

Dependent variableComparisonsp valueEffect sizePower
a1 VMH mean Iba1-irMain effect of hormones
Main effect of treatment
Interaction		0.0047
<0.0001		0.350
0.747		0.207
a2 VMH number of microgliaMain effect of hormones
Main effect of treatment
Interaction		0.0261
<0.0001		0.234
0.822		0.207
a3 VMH total cell body areaMain effect of hormones
Main effect of treatment
Interaction		0.0250
<0.0001		0.238
0.926		0.207
a4 VMH mean cell body areaMain effect of hormones
Main effect of treatment
Interaction		0.1917
<0.0001		0.088
0.901		0.207
a5 VMH total outgrowthMain effect of hormones
Main effect of treatment
Interaction		0.895
<0.0001		0.001
0.718		0.207
a6 VMH mean outgrowthMain effect of hormones
Main effect of treatment
Interaction		0.2159
<0.0001		0.079
0.866		0.207
a7 VMH total processesMain effect of hormones
Main effect of treatment
Interaction		0.1779
<0.0001		0.094
0.713		0.207
a8 VMH total branchesMain effect of hormones
Main effect of treatment
Interaction		0.6455
<0.0001		0.011
0.773		0.207
a9 VMH microglial ratioMain effect of ratio
Main effect of treatment
Interaction		<0.0001
0.04
<0.0001		0.424
0.103
0.742		0.207
b1 IL-1α 6 hMain effect of hormones
Main effect of treatment
Interaction		0.495
0.781
0.077		0.043
0.011
0.256		0.144
b2 IL-1β 6 h--------
b3 IL-6 6 hMain effect of hormones
Main effect of treatment
Interaction		0.667
0.008
0.664		0.019
0.517
0.019		0.136
b4 IL-10 6 hMain effect of hormones
Main effect of treatment
Interaction		0.008
<0.0001
0.008		0.482
0.769
0.492		0.144
b5 TNF-α 6 hMain effect of hormones
Main effect of treatment
Interaction		0.053
<0.0001
0.017		0.132
0.938
0.451		0.136
b6 Change in body weight 6 hEffect of hormone
Main effect of treatment
Interaction		0.2662
<0.0001
0.0258		0.065
0.902
0.235		0.207
c1 IL-1α 24 hMain effect of hormones
Main effect of treatment
Interaction		0.333
0.0003
0.031		0.059
0.562
0.260		0.183
c2 IL-1β 24 hMain effect of hormones
Main effect of treatment
Interaction		0.718
0.514
0.379		0.049
0.153
0.261		0.077
c3 IL-6 24 hMain effect of hormones
Main effect of treatment
Interaction		0.631
0.0003
0.117		0.101
0.623
0.165		0.167
c4 IL-10 24 hMain effect of hormones
Main effect of treatment
Interaction		0.2599
0.085
0.26205		0.096
0.211
0.019		0.159
c5 TNF-α 24 hMain effect of hormones
Main effect of treatment
Interaction		0.257
0.739
0.6751		0.019
0.054
0.014		0.159
c6 Change in body weight 24 hEffect of hormone
Main effect of treatment
Interaction		0.792
<0.0001
0.099		0.003
0.816
0.129		0.207
d1 EstradiolMain effect of hormone<0.00010.8400.269
e1 Change in temperatureMain effect of time
Main effect of treatment
Interaction		<0.0001
0.005
<0.0001		0.335
0.204
0.127		0.128
e2 Change in locomotionMain effect of time
Main effect of treatment
Interaction		<0.0001
<0.0001
<0.0001		0.298
0.224
0.281		0.128

  • Experiment 1. The effect of estradiol on microglial, cytokine, and physiological response to LPS.