Dependent variable | Comparison | p value | Effect size | Power | |
---|---|---|---|---|---|
f1 | VMH mean Iba1-ir | Main effect of drug Main effect of treatment Interaction | 0.0556 <0.0001 | 0.129 0.868 | 0.269 |
f2 | VMH number of microglia | Main effect of drug Main effect of treatment Interaction | 0.2079 <0.0001 | 0.060 0.794 | 0.261 |
f3 | VMH total cell body area | Main effect of drug Main effect of treatment Interaction | 0.4003 <0.0001 | 0.027 0.876 | 0.261 |
f4 | VMH mean cell body area | Main effect of drug Main effect of treatment Interaction | 0.513 <0.0001 | 0.017 0.927 | 0.261 |
f5 | VMH total outgrowth | Main effect of drug Main effect of treatment Interaction | 0.005 0.033 | 0.267 0.164 | 0.261 |
f6 | VMH mean outgrowth | Main effect of drug Main effect of treatment Interaction | 0.364 <0.0001 | 0.032 0.745 | 0.261 |
f7 | VMH total processes | Main effect of drug Main effect of treatment Interaction | 0.098 <0.0001 | 0.2101 0.775 | 0.261 |
f8 | VMH total branches | Main effect of drug Main effect of treatment Interaction | 0.011 <0.0001 | 0.224 0.570 | 0.261 |
f9 | VMH microglial ratio | Main effect of ratio Main effect of treatment Interaction | <0.0001 <0.0001 <0.0001 | 0.773 0.546 0.440 | 0.184 |
g1 | IL-1α 6 h | Main effect of drug Main effect of treatment Interaction | 0.781 0.519 0.482 | 0.004 0.024 0.028 | 0.199 |
g2 | IL-1β 6 h | Main effect of drug Main effect of treatment Interaction | 0.347 <0.0001 0.01 | 0.052 0.767 0.332 | 0.191 |
g3 | IL-6 6 h | Main effect of drug Main effect of treatment Interaction | 0.040 0.001 0.040 | 0.213 0.566 0.213 | 0.199 |
g4 | IL-10 6 h | Main effect of drug Main effect of treatment Interaction | 0.682 <0.0001 0.642 | 0.011 0.737 0.013 | 0.183 |
g5 | TNF-α 6 h | Main effect of drug Main effect of treatment Interaction | 0.219 <0.0001 0.023 | 0.078 0.841 0.243 | 0.207 |
g6 | Change in body weight 6 h | Main effect of drug Main effect of treatment Interaction | 0.168 <0.0001 0.107 | 0.098 0.921 0.131 | 0.207 |
h1 | IL-1α 24 h | Main effect of drug Main effect of treatment Interaction | 0.325 0.041 0.946 | 0.057 0.223 0.000 | 0.191 |
h2 | IL-1β 24 h | Two-way ANOVA | -- | -- | -- |
h3 | IL-6 24 h | Main effect of drug Main effect of treatment Interaction | 0.768 0.003 0.667 | 0.008 0.576 0.017 | 0.143 |
h4 | IL-10 24 h | Main effect of drug Main effect of treatment Interaction | 0.977 0.003 0.763 | 0.000 0.469 0.006 | 0.167 |
h5 | TNF-α 24 h | Main effect of drug Main effect of treatment Interaction | 0.441 0.180 0.178 | 0.035 0.103 0.104 | 0.191 |
h6 | Change in body weight 24 h | Main effect of drug Main effect of treatment Interaction | 0.281 <0.0001 0.752 | 0.058 0.784 0.005 | 0.214 |
i1 | Change in temperature | Main effect of time Main effect of treatment Interaction | <0.0001 <0.0001 0.145 | 0.098 0.046 0.113 | 0.206 |
i2 | Change in locomotion | Main effect of time Main effect of treatment Interaction | <0.0001 <0.0001 0.206 | 0.150 0.162 0.106 | 0.206 |
Experiment 2. The effect of formestane on the microglial, cytokine, and physiological response to LPS