Table 1

Description of statistical tests and associated values used throughout the study

FigureStatistical testStatistical values
1A Unpaired t test with Welch's correctionp = 0.03; t = 2.789, df = 3
1B, leftOne-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.0044, F = 7.191, 1 vs 2 (training session): p < 0.05, CI of diff = 23.74–217.9; 1 vs 3 (training session): p < 0.01, CI of diff = 47.11–241.3
1B, rightOne-way ANOVA, Dunnett's multiple comparison test.One-way ANOVA p = 0.0006, F = 11.68, 1 vs 2 (training session): p < 0.01, CI of diff = 63.81–239.3; 1 vs 3 (training session): p < 0.001, CI of diff = 66.88–242.3
1C, leftUnpaired t test with Welch's correctionp = 0.04, t = 2.85, df = 9
1C, rightUnpaired t test with Welch's correctionp = 0.03, t = 2.501, df = 9
1D Unpaired t test with Welch's correctionp = 0.0037; t = 3.436, df = 15
1E Unpaired t test with Welch's correctionp = 0.84; t = 0.2118, df = 5
1F, leftOne-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.0136, F = 6.288, 1 vs 2 (training session): p > 0.05, CI of diff = –12.74 to 207.3; 1 vs 3 (training session): p < 0.01, CI of diff = 44.13–264.2
1F, rightOne-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.0156, F = 5.688, 1 vs 2 (training session): p > 0.05, CI of diff = –3.202 to 221.3; 1 vs 3 (training session): p < 0.05, CI of diff = 36.56–261.1
1G, leftUnpaired t test with Welch's correctionp = 0.547, t = 0.6258, df = 9
1G, rightUnpaired t test with Welch's correctionp = 0.48, t = 0.7431, df = 9
1H, leftUnpaired t test with Welch's correctionp = 0.2120, t = 1.356, df = 8
2A One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.0004, F = 10.20; control vs AP5: p < 0.01, CI of diff = 21.28–62.13; control vs 10-IH: p < 0.01, CI of diff = 5.21–44.71; control vs 10-IH+AP5: p < 0.01, CI of diff = 11.04–51.89
2B One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p < 0.0001, F = 116.9; control vs AP5: p < 0.01, CI of diff = 54.80–80.72; control vs 10-IH: p < 0.01, CI of diff = 56.41–82.32
2C Unpaired t test with Welch’s correctionp = 0.94; t = 0.065, df = 13.14
2D One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p < 0.0001, F = 54.50; 0-HIF1a+/− vs 10-HIF1a+/−: p > 0.05, CI of diff = –20.49 to 10.15; 10-HIF1a+/− vs 10-HIF1a+/−+ AP5: p < 0.01, CI of diff = 42.75–75.42
3B, topOne-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.56, F = 0.70; control vs IH10: p > 0.05, CI of diff = –24.53 to 54.60; control vs 0-HIF1a+/−: p > 0.05, CI of diff = –20.36 to 54.60; control vs 10-HIF1a+/−: p > 0.05, CI of diff = –33.12 to 39.06
3B, bottomOne-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.56, F = 0.70; control vs IH10: p < 0.05, CI of diff = –70.53 to –6.241; control vs 0-HIF1a+/−: p > 0.05, CI of diff = –56.75 to 3.840; control vs 10-HIF1a+/−: p > 0.05, CI of diff = –40.38 to 17.97
3C One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.014, F = 4.74; control vs IH10: p < 0.05, CI of diff = 0.96–0.78 ; control vs 0-HIF1a+/−: p > 0.05, CI of diff = –0.38 to 0.05; control vs 10-HIF1a+/−: p > 0.05, CI of diff = –0.27 to 0.157
3D One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.14, F = 2.39; control vs IH10: p > 0.05, CI of diff = –0.42 to 0.27 ; control vs 0-HIF1a+/−: p > 0.05, CI of diff = –0.63 to 0.0636; control vs 10-HIF1a+/−: p > 0.05, CI of diff = –0.35 to 0.33
4A One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.006 F = 6.871, control vs IH10: p < 0.01 CI of diff = –105.1 to –17.65; control vs 0-HIF1a+/−: p > 0.05 CI of diff = –52.12 to 35.32; control vs 10-HIF1a+/−: p > 0.05 CI of diff = –40.58 to 46.85
4B One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.003, F = 11.70; control vs IH10: p > 0.05, CI of diff = –1.85 to –0.28; control vs 0-HIF1a+/−: p > 0.05, CI of diff = –0.35 to 0.45; control vs 10-HIF1a+/−: p > 0.05, CI of diff = –0.28 to 0.52
5A One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p = 0.0023, F = 10.00; control vs IH10: p < 0.01, CI of diff = 0.09–0.75; control vs 10-MnTMPyP: p > 0.05, CI of diff = –0.49 to 0.26
5B One-way ANOVA, Dunnett's multiple comparison testOne-way ANOVA p < 0.0001, F = 57.60, control vs IH: p < 0.001, CI of diff = 50.58–88.15; control vs IH+MnTMPyP: p > 0.05, CI of diff = –19.59 to 17.98
5C, topOne-way ANOVA, Dunnett’s multiple comparison testOne-way ANOVA p = 0.0008, F = 6.32, 1 vs 2 (training session): p > 0.05, CI of diff = –40.99 to 139.5; 1 vs 3 (training session): p < 0.001, CI of diff = 71.59–252.1
5C, bottomOne-way ANOVA, Dunnett’s multiple comparison testOne-way ANOVA p = 0.0056, F = 9.10, 1 vs 2 (training session): p > 0.05, CI of diff = –25.40 to 187.3; 1 vs 3 (training session): p < 0.01, CI of diff = 55.75–268.4
5D Unpaired t test with Welch’s correctionp = 0.0005; t = 4.292, df = 16.7112