Table 1

Statistics table

	Figure	Group comparison	Datastructure	Type of test	p value	Effectsize	95% CI (lower toupper bound)
a	1F	Treatment	Normal	One-way ANOVA	<0.0001
		Control vs Tat (4 h)		Tukey’s post hoc	0.5864^*	–11.8% DSE	–22.5 to 0.13
		Control vs Tat (24 h)		Tukey’s post hoc	0.0002^*	–41.8% DSE	–55.6 to –27.4
		Control vs Tat (48 h)		Tukey’s post hoc	<0.0001^*	–46.8% DSE	–60.7 to –32.8
		Control vs hi-Tat (24 h)		Tukey’s post hoc	0.9759^*	4.6% DSE	–9.06 to 19.6
		hi-Tat (24 h) vs Tat (24 h)		Tukey’s post hoc	<0.0001^*	–46.5% DSE	–63.2 to –30.2
		hi-Tat (24 h) vs Tat (48 h)		Tukey’s post hoc	<0.001^*	–51.5% DSE	–68.7 to –36.6
b		EPSC: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.3641	–35.6 pA	–124.1 to 21.3
		IPSC: control vs Tat (24 h)	Normal^#	Welch’s t test (two-tailed)	0.3406	–97.5 pA	–329.3 to 68.3
c	2D	Depolarization duration × Tat treatment	Normal	Two-way ANOVA: interaction	0.9182
		Depolarization duration		Factor	0.0007
		Tat treatment		Factor	0.9365
d	3C	Control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.0001	–24.5% MSE	–31.2 to –18.5
e	4C	Tau: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.7611	–0.4361 s	–3.554 to 2.680^§
		Peak: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.8827	–0.0411	–0.646 to 0.564^§
f	5C	2-AG EC₅₀: control vs Tat (24 h)	Normal^#	Welch’s t test (two-tailed)	<0.0001	1.22 µM	0.716 to 1.724^§
	5D	JZL184 treatment × Tat treatment	Normal	Two-way ANOVA: interaction	0.8380
		JZL184 treatment		Factor	0.3572
		Tat treatment		Factor	<0.0001
g	6D	Win-2 EC₅₀: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.93	–0.16 nM	–3.81 to 4.13^§
h	7D	[THC] × Tat treatment	Normal	Two-way ANOVA: interaction	0.9165
		Tat treatment		Factor	<0.0001
		[THC]		Factor	0.0111
i		RAP (24 h) × Tat (24 h)	Normal	Two-way ANOVA: interaction	0.6978
		RAP (24 h) treatment		Factor	0.9528
		Tat (24 h) treatment		Factor	<0.0001
j	8B	CPA: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.6862	2.65%	–9.05 to 13.9
	8C	CAP: control vs Tat (24 h)	Normal	Unpaired t test (two-tailed)	0.8557	–1.83%	–21.9 to 14.7

Effect size is calculated as the mean difference.
↵* p values have been corrected for multiple comparisons.
↵# unequal variance.
↵^§CI derived from error associated with curve fit.