Uninjured (238) | 3 DPI (249) | 7 DPI (258) | Uninjured,3 DPI, and 7 DPIintersect (226) | |||
---|---|---|---|---|---|---|
Adipoq | Adipoq | Adipoq | Adipoq | |||
Adm | Adm | Adm | Adm | |||
Agt | Agt | Agt | Agt | |||
Angpt1 | Angpt1 | Angpt1 | Angpt1 | |||
Angpt2 | Angpt2 | Angpt2 | Angpt2 | |||
Angpt4 | Angpt4 | Angpt4 | Angpt4 | |||
Apln | Apln | Apln | Apln | |||
Artn | Areg++ | Areg++ | Artn | |||
Avp | Artn | Artn | Avp | |||
Bdnf | Avp | Avp | Bdnf | |||
Bmp1 | Bdnf | Bdnf | Bmp1 | |||
Bmp2 | Bmp1 | Bmp1 | Bmp2 | |||
Bmp4 | Bmp2 | Bmp2 | Bmp4 | |||
Bmp5 | Bmp4 | Bmp4 | Bmp5 | |||
Bmp6 | Bmp5 | Bmp5 | Bmp6 | |||
Bmp7 | Bmp6 | Bmp6 | Bmp7 | |||
Btc | Bmp7 | Bmp7 | Btc | |||
Cck | Btc | Btc | Cck | |||
Ccl11 | Cck | Btla+ | Ccl11 | |||
Ccl19 | Ccl11 | Calca+ | Ccl19 | |||
Ccl2 | Ccl17* * | Cck | Ccl2 | |||
Ccl21 | Ccl19 | Ccl11 | Ccl21 | |||
Ccl22 | Ccl2 | Ccl19 | Ccl22 | |||
Ccl24 | Ccl20++ | Ccl2 | Ccl24 | |||
Ccl25 | Ccl21 | Ccl20++ | Ccl25 | |||
Ccl27 | Ccl22 | Ccl21 | Ccl27 | |||
Ccl3 | Ccl24 | Ccl22 | Ccl3 | |||
Ccl5 | Ccl25 | Ccl24 | Ccl5 | |||
Ccl7 | Ccl27 | Ccl25 | Ccl7 | |||
Clcf1 | Ccl3 | Ccl27 | Clcf1 | |||
Clu | Ccl5 | Ccl3 | Clu | |||
Cmtm8 | Ccl7 | Ccl5 | Cmtm8 | |||
Cntf | Cga++ | Ccl7 | Cntf | |||
Cntn1 | Clcf1 | Cga++ | Cntn1 | |||
Cntn2 | Clu | Clcf1 | Cntn2 | |||
Copa | Cmtm8 | Clu | Copa | |||
Crlf1 | Cntf | Cmtm8 | Crlf1 | |||
Csf1 | Cntn1 | Cntf | Csf1 | |||
Cst3 | Cntn2 | Cntn1 | Cst3 | |||
Ctf1 | Copa | Cntn2 | Ctf1 | |||
Ctgf | Crlf1 | Copa | Ctgf | |||
Cx3cl1 | Csf1 | Crlf1 | Cx3cl1 | |||
Cxcl1 | Cst3 | Csf1 | Cxcl1 | |||
Cxcl10 | Ctf1 | Cst3 | Cxcl10 | |||
Cxcl12 | Ctgf | Ctf1 | Cxcl12 | |||
Cxcl13 | Cx3cl1 | Ctgf | Cxcl13 | |||
Cxcl16 | Cxcl1 | Cx3cl1 | Cxcl16 | |||
Cxcl2 | Cxcl10 | Cxcl1 | Cxcl2 | |||
Cxcl9 | Cxcl12 | Cxcl10 | Cxcl9 | |||
Dhh | Cxcl13 | Cxcl11+ | Dhh | |||
Dll1 | Cxcl16 | Cxcl12 | Dll1 | |||
Dll4 | Cxcl2 | Cxcl13 | Dll4 | |||
Ebi3 | Cxcl9 | Cxcl16 | Ebi3 | |||
Eda | Dhh | Cxcl2 | Eda | |||
Edn3 | Dll1 | Cxcl9 | Edn3 | |||
Efna1 | Dll4 | Dhh | Efna1 | |||
Efna2 | Ebi3 | Dll1 | Efna2 | |||
Efna4 | Eda | Dll4 | Efna4 | |||
Efna5 | Edn3 | Ebi3 | Efna5 | |||
Efnb1 | Efna1 | Eda | Efnb1 | |||
Efnb2 | Efna2 | Edn3 | Efnb2 | |||
Efnb3 | Efna4 | Efna1 | Efnb3 | |||
Epo | Efna5 | Efna2 | Epo | |||
Esm1 | Efnb1 | Efna4 | Esm1 | |||
Fgf1 | Efnb2 | Efna5 | Fgf1 | |||
Fgf10 | Efnb3 | Efnb1 | Fgf17 | |||
Fgf17 | Epo | Efnb2 | Fgf18 | |||
Fgf18 | Esm1 | Efnb3 | Fgf19 | |||
Fgf19 | Fgf1 | Epo | Fgf2 | |||
Fgf2 | Fgf17 | Esm1 | Fgf4 | |||
Fgf4 | Fgf18 | Fgf1 | Fgf5 | |||
Fgf5 | Fgf19 | Fgf10 | Fgf7 | |||
Fgf7 | Fgf2 | Fgf17 | Figf | |||
Figf | Fgf4 | Fgf18 | Fjx1 | |||
Fjx1 | Fgf5 | Fgf19 | Flt3lg | |||
Flt3lg | Fgf7 | Fgf2 | Fstl1 | |||
Fstl1 | Figf | Fgf23+ | Gal | |||
Gal | Fjx1 | Fgf4 | Gap43 | |||
Gap43 | Flt3lg | Fgf5 | Gas6 | |||
Gas6 | Fstl1 | Fgf7 | Gdf10 | |||
Gdf10 | Gal | Figf | Gdf11 | |||
Gdf11 | Gap43 | Fjx1 | Gdf9 | |||
Gdf9 | Gas6 | Flt3lg | Gdnf | |||
Gdnf | Gdf10 | Fstl1 | Ghrh | |||
Ghrh | Gdf11 | Gal | Gip | |||
Gip | Gdf5++ | Gap43 | Gmfb | |||
Gmfb | Gdf6* * | Gas6 | Gmfg | |||
Gmfg | Gdf9 | Gdf10 | Gnrh1 | |||
Gnrh1 | Gdnf | Gdf11 | Gpi | |||
Gpi | Gh1* * | Gdf5++ | Grp | |||
Grp | Ghrh | Gdf9 | Habp2 | |||
Guca2a | Gip | Gdnf | Hbegf | |||
Habp2 | Gmfb | Ghrh | Hcrt | |||
Hbegf | Gmfg | Gip | Hdgf | |||
Hcrt | Gnrh1 | Gmfb | Hdgfrp3 | |||
Hdgf | Gpi | Gmfg | Hgf | |||
Hdgfrp3 | Grp | Gnrh1 | Hmgb1 | |||
Hgf | Habp2 | Gpi | Ifna4 | |||
Hmgb1 | Hbegf | Grp | Igf1 | |||
Ifna1 | Hcrt | Guca2a | Igf2 | |||
Ifna4 | Hdgf | Habp2 | Igfbpl1 | |||
Igf1 | Hdgfrp3 | Hbegf | Ihh | |||
Igf2 | Hgf | Hcrt | Il13 | |||
Igfbpl1 | Hmgb1 | Hdgf | Il15 | |||
Ihh | Ifna4 | Hdgfrp3 | Il16 | |||
Il13 | Igf1 | Hgf | Il17b | |||
Il15 | Igf2 | Hmgb1 | Il18 | |||
Il16 | Igfbpl1 | Ifna1 | Il19 | |||
Il17b | Ihh | Ifna4 | Il23a | |||
Il18 | Il12a++ | Igf1 | Il25 | |||
Il19 | Il13 | Igf2 | Il33 | |||
Il21* | Il15 | Igfbpl1 | Inha | |||
Il23a | Il16 | Ihh | Inhba | |||
Il25 | Il17b | Il12a++ | Inhbb | |||
Il33 | Il18 | Il13 | Insl3 | |||
Inha | Il19 | Il15 | Jag1 | |||
Inhba | Il23a | Il16 | Jag2 | |||
Inhbb | Il25 | Il17b | Kiss1 | |||
Insl3 | Il27* * | Il18 | Kitlg | |||
Jag1 | Il33 | Il19 | Lgals3 | |||
Jag2 | Il6++ | Il1b+ | Lif | |||
Kiss1 | Inha | Il23a | Lrsam1 | |||
Kitlg | Inhba | Il25 | Ltb | |||
Lgals3 | Inhbb | Il33 | Mdk | |||
Lgi1 | Inhbe++ | Il6++ | Metrn | |||
Lif | Insl3 | Inha | Mif | |||
Lrrc4 | Jag1 | Inhba | Mln | |||
Lrsam1 | Jag2 | Inhbb | Nampt | |||
Ltb | Kiss1 | Inhbe++ | Nenf | |||
Mdk | Kitlg | Insl3 | Ngf | |||
Metrn | Lgals3 | Jag1 | Nodal | |||
Mif | Lgi1 | Jag2 | Nov | |||
Mln | Lif | Kiss1 | Npb | |||
Mst1* | Lrsam1 | Kitlg | Npff | |||
Nampt | Ltb | Lgals3 | Nppb | |||
Nenf | Mdk | Lif | Nppc | |||
Ngf | Metrn | Lrrc4 | Nrtn | |||
Nodal | Mif | Lrsam1 | Ntf3 | |||
Nov | Mln | Ltb | Ntf4 | |||
Npb | Mmp12++ | Mdk | Ntn1 | |||
Npff | Mmp9++ | Metrn | Osm | |||
Nppb | Nampt | Mif | Oxt | |||
Nppc | Nell2++ | Mln | Pcsk1n | |||
Nrtn | Nenf | Mmp12++ | Pdap1 | |||
Ntf3 | Ngf | Mmp9++ | Pdgfa | |||
Ntf4 | Nodal | Nampt | Pdgfb | |||
Ntn1 | Nov | Nell2++ | Pdgfc | |||
Osm | Npb | Nenf | Pf4 | |||
Oxt | Npff | Ngf | Pgf | |||
Pcsk1n | Nppb | Nodal | Plg | |||
Pdap1 | Nppc | Nov | Pnoc | |||
Pdgfa | Nrtn | Npb | Prdx2 | |||
Pdgfb | Ntf3 | Npff | Prdx6 | |||
Pdgfc | Ntf4 | Nppb | Prlh | |||
Pf4 | Ntn1 | Nppc | Proc | |||
Pgf | Osm | Nrg1+ | Prok1 | |||
Plg | Oxt | Nrtn | Prok2 | |||
Pnoc | Pcsk1n | Ntf3 | Psip1 | |||
Prdx2 | Pdap1 | Ntf4 | Pspn | |||
Prdx6 | Pdgfa | Ntn1 | Pth2 | |||
Prlh | Pdgfb | Osm | Pthlh | |||
Proc | Pdgfc | Oxt | Ptn | |||
Prok1 | Pf4 | Pcsk1n | Rabep1 | |||
Prok2 | Pgf | Pdap1 | Rln3 | |||
Psip1 | Plg | Pdgfa | Rspo1 | |||
Pspn | Pnoc | Pdgfb | Rtn1 | |||
Pth2 | Ppy++ | Pdgfc | Rtn4 | |||
Pthlh | Prdx2 | Pf4 | S100b | |||
Ptn | Prdx6 | Pgf | Scgb3a1 | |||
Rabep1 | Prlh | Plg | Scrn1 | |||
Rln3 | Proc | Pnoc | Sct | |||
Rspo1 | Prok1 | Pomc+ | Sema3a | |||
Rspo3 | Prok2 | Ppbp+ | Sema3b | |||
Rspo4* | Psip1 | Ppy++ | Sema3c | |||
Rtn1 | Pspn | Prdx2 | Sema3d | |||
Rtn4 | Pth2 | Prdx6 | Sema3e | |||
S100b | Pthlh | Prlh | Sema3f | |||
Scg3* | Ptn | Proc | Sema3g | |||
Scgb3a1 | Rabep1 | Prok1 | Sema4a | |||
Scrn1 | Rln3 | Prok2 | Sema4b | |||
Sct | Rspo1 | Psip1 | Sema4c | |||
Sema3a | Rtn1 | Pspn | Sema4d | |||
Sema3b | Rtn4 | Pth2 | Sema4g | |||
Sema3c | S100b | Pthlh | Sema5a | |||
Sema3d | Scgb3a1 | Ptn | Sema5b | |||
Sema3e | Scrn1 | Rabep1 | Sema6a | |||
Sema3f | Sct | Rln3 | Sema6b | |||
Sema3g | Sema3a | Rspo1 | Sema6c | |||
Sema4a | Sema3b | Rspo3 | Sema6d | |||
Sema4b | Sema3c | Rtn1 | Sema7a | |||
Sema4c | Sema3d | Rtn4 | Serpinh1 | |||
Sema4d | Sema3e | S100b | Sfrp1 | |||
Sema4g | Sema3f | Scgb3a1 | Sfrp2 | |||
Sema5a | Sema3g | Scrn1 | Sfrp4 | |||
Sema5b | Sema4a | Sct | Sfrp5 | |||
Sema6a | Sema4b | Sema3a | Shh | |||
Sema6b | Sema4c | Sema3b | Smoc1 | |||
Sema6c | Sema4d | Sema3c | Sost | |||
Sema6d | Sema4f++ | Sema3d | Sparc | |||
Sema7a | Sema4g | Sema3e | Sparcl1 | |||
Serpinh1 | Sema5a | Sema3f | Spp1 | |||
Sez6 | Sema5b | Sema3g | Sst | |||
Sfrp1 | Sema6a | Sema4a | Tgfa | |||
Sfrp2 | Sema6b | Sema4b | Tgfb1 | |||
Sfrp4 | Sema6c | Sema4c | Tgfb2 | |||
Sfrp5 | Sema6d | Sema4d | Tgfb3 | |||
Shh | Sema7a | Sema4f++ | Thpo | |||
Smoc1 | Serpinh1 | Sema4g | Timp2 | |||
Sost | Sez6 | Sema5a | Tnf | |||
Sparc | Sfrp1 | Sema5b | Tnfrsf11b | |||
Sparcl1 | Sfrp2 | Sema6a | Tnfsf10 | |||
Spp1 | Sfrp4 | Sema6b | Tnfsf11 | |||
Sst | Sfrp5 | Sema6c | Tnfsf12 | |||
Tgfa | Shh | Sema6d | Tnfsf13 | |||
Tgfb1 | Smoc1 | Sema7a | Tnfsf14 | |||
Tgfb2 | Sost | Serpinh1 | Tnfsf15 | |||
Tgfb3 | Sparc | Sfrp1 | Tymp | |||
Thpo | Sparcl1 | Sfrp2 | Ucn2 | |||
Timp2 | Spp1 | Sfrp4 | Ucn3 | |||
Tnf | Sst | Sfrp5 | Vegfa | |||
Tnfrsf11a* | Tgfa | Shh | Vegfb | |||
Tnfrsf11b | Tgfb1 | Smoc1 | Vegfc | |||
Tnfsf10 | Tgfb2 | Sost | Wnt2 | |||
Tnfsf11 | Tgfb3 | Sparc | Wnt5a | |||
Tnfsf12 | Thpo | Sparcl1 | Wnt11 | |||
Tnfsf13 | Timp2 | Spp1 | Xcl1 | |||
Tnfsf14 | Tnf | Sst | ||||
Tnfsf15 | Tnfrsf11b | Tdgf1+ | ||||
Tymp | Tnfsf10 | Tgfa | ||||
Ucn2 | Tnfsf11 | Tgfb1 | ||||
Ucn3 | Tnfsf12 | Tgfb2 | ||||
Vegfa | Tnfsf13 | Tgfb3 | ||||
Vegfb | Tnfsf13b++ | Thpo | ||||
Vegfc | Tnfsf14 | Timp2 | ||||
Wnt2 | Tnfsf15 | Tnf | ||||
Wnt5a | Tnfsf8++ | Tnfrsf11b | ||||
Wnt11 | Tnfsf9++ | Tnfsf10 | ||||
Xcl1 | Tslp++ | Tnfsf11 | ||||
Tymp | Tnfsf12 | |||||
Ucn2 | Tnfsf13 | |||||
Ucn3 | Tnfsf13b++ | |||||
Vegfa | Tnfsf14 | |||||
Vegfb | Tnfsf15 | |||||
Vegfc | Tnfsf8++ | |||||
Wnt2 | Tnfsf9++ | |||||
Wnt5a | Tslp++ | |||||
Wnt7a++ | Tymp | |||||
Wnt11 | Ucn2 | |||||
Xcl1 | Ucn3 | |||||
Vegfa | ||||||
Vegfb | ||||||
Vegfc | ||||||
Wnt1+ | ||||||
Wnt2 | ||||||
Wnt5a | ||||||
Wnt7a++ | ||||||
Wnt11 | ||||||
Xcl1 |
Ligands identified in 3 DPI, 7 DPI, and uninjured rat sciatic nerves based on microarray analysis and our curated ligand-receptor database (modified from Yuzwa et al., 2016). Ligands were considered expressed if their expression levels exceeded that of Ntf3 mRNA. Ligands expressed only in the uninjured nerve are indicated by one asterisk, only in the 3 DPI nerve by two asterisks, and only in the 7 DPI nerve by one plus sign. Ligands expressed in the 3 and 7 DPI nerves but not in the uninjured nerve are indicated by two plus signs. Also shown in a separate column are ligands expressed in all populations (intersect).
* uninjured only.
** 3 DPI only.
+ 7 DPI only.
++ 3 DPI and 7 DPI intersect.