Results from the mixed linear model for total number of activated pixels and PPR using VSDI in the DG of homozygous transgenic animals (+/+) and controls (–/–)
| Mean (SD) | p values for test of fixed effects | ||||
|---|---|---|---|---|---|
| –/– | +/+ | Genotype | Sex | N (slices/animals) | |
| Activated pixels (1 pulse) | |||||
| 3 months | 807 (284) | 83 (297) | 0.549 | 0.463 | 13/7 |
| 9 months | 1698 (579) | 1800 (279) | 0.641 | 0.638 | 21/10 |
| 12 months | 1687 (485) | 1581 (427) | 0.564 | 0.733 | 23/9 |
| PPR: normal ACSF | |||||
| 9 months | 0.860 (0.098) | 0.811 (0.032) | 0.157 | 0.198 | 21/10 |
| 12 months | 0.920 (0.119) | 0.854 (0.098) | 0.190 | 0.718 | 23/9 |
| PPR: bicuculline | |||||
| 9 months | 1.320 (0.076) | 1.321 (0.082) | 0.970 | 0.897 | 15/8 |
| 12 months | 1.373 (0.088) | 1.363 (0.070) | 0.859 | 0.782 | 15/9 |