Estimated marginal means | p values for test of fixed effects | |||||
---|---|---|---|---|---|---|
–/– | +/+ | Genotype | Age | Sex | ||
a | Input resistance (MΩ) | 138.0 | 129.8 | 0.299 | 0.085 | 0.013 1 |
b | Time constant, τ (ms) | 28.9 | 30.7 | 0.230 | 0.746 | 0.001 2 |
c | Sag ratio | 0.803 | 0.799 | 0.776 | 0.284 | 0.890 |
d | Rebound (mV) | 5.45 | 5.51 | 0.926 | 0.534 | 0.666 |
e | Vm (mV) | –69.3 | –70.7 | 0.126 | 0.022 3 | 0.204 |
f | Rheobase (pA) | 71 | 72 | 0.934 | 0.034 4 | 0.006 5 |
g | AP threshold (mV) | –45.0 | –46.8 | 0.054 | 0.313 | 0.119 |
h | AP amplitude (mV) | 91.8 | 91.7 | 0.898 | 0.563 | 0.098 |
i | AP half width (ms) | 1.071 | 1.128 | 0.152 | 0.665 | 0.659 |
Basic electrophysiological and AP properties from all individual cells are represented in Extended Data Table 1-1; n = 111 cells from 40 animals. Vm, resting membrane potential. Values printed in bold face identify significance.
↵ 1Effect size: 21.9 MΩ (males higher). 2Effect size: 5.6 ms (males higher). 3Effect size: –2.2 mV. 4Effect size: 18.9 pA. 5Effect size: 24.5 pA (males lower).