Table 3.

Effect of MIA at E17.5 on the regulation of interneurons fate determination and migration-related transcripts

Gene symbolGene nameFold changeSEMSignificance
gad1 (gad67)Glutamate decarboxylase 1 1.110.07
gad2 (gad65)Glutamate decarboxylase 21.570.07*
nkx2.1NK2 homeobox 12.420.29***
ascl1 (mash1)Achaete-scute family bHLH transcription factor 11.390.09
pax6Paired box 61.020.16
lhx6LIM homeobox protein 61.920.19*
ki67Antigen identified by monoclonal antibody Ki671.620.08*
dlx1Distal-less homeobox 11.510.07*
dlx2Distal-less homeobox 21.120.17
dlx5Distal-less homeobox 52.760.53***
dlx6Distal-less homeobox 60.980.10
  • Quantification of mRNA levels in E17.5 embryos. Each value represents the mean (±SEM) from at least five embryos out of at least two pregnancies; *p < 0.05; ***p < 0.001 (Mann–Whitney).