Potassium channel subunits in the OB
| Gene | K+- channelsubunit | ChIPseq peak1 | ABA expression in OB2 | Current3 | |||
|---|---|---|---|---|---|---|---|
| Strub42011 | Laurette52015 | Young62014 | Calero-Nieto7 2014 | ||||
| Kcna1 | Kv1.1 | No | No | No | No | Low expression in GCL | IDR |
| Kcna2 | Kv1.2 | Yes | Yes | No | No | Expressed in MCL and ETC | IDR |
| Kcna3 | Kv1.3 | No | Yes | No | No | Expressed in MCL and ETC | IDR |
| Kcna4 | Kv1.4 | No | No | No | No | Expressed in MCL, ETC and GCL | IA |
| Kcna5 | Kv1.5 | No | No | No | No | Low expression in ETC | IA with β-subunitKvB3 |
| Kcnc1 | Kv3.1 | No | No | No | No | Expressed in MCL and ETC | IDR |
| Kcnc2 | Kv3.2 | No | No | No | No | Expressed in PGC, ETC, MCL | IDR |
| Kcnc3 | Kv3.3 | No | No | No | No | Expressed in MCL and ETC | IA |
| Kcnc4 | Kv3.4 | No | No | No | No | Low expression in MCL | IA |
| Kcnd1 | Kv4.1 | No | No | No | No | Expressed throughout the OB | IA |
| Kcnd2 | Kv4.2 | No | No | No | No | Expressed in MCL and GCL | IA |
| Kcnd3 | Kv4.3 | Yes | Yes | No | No | Expressed throughout the OB | IA |
Available ChIPseq data, Allen Brain Atlas expression of potassium channel subunits in the OB and published data on the type of current these subunits are regulating.
↵1 “No” indicates that no peak observed was higher than negative control, whereas “yes” indicates that the peak observed was higher than the negative control. Region screened encompassed whole intronic regions and approximately 2 kbp up and downstream of transcription start site.
↵2 GCL, PGC = periglomerular cells.
↵3 IDR = delayed rectifying current, IA= A-type current Gutman et al. (2005).
↵4 GEO Accession number GSE64137.
↵5 GEO Accession number GSM1517751.
↵6 GEO Accession number GSM1567047.
↵7 GEO Accession number GSM1167584.