Statistical analyses used within the manuscript
| Data structure | Type of test | Comparison | 95% confidence interval | |
|---|---|---|---|---|
| Figure 2A | Non-normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Morphine vs vehicle | 0.864 to 1.719 | ||
| Morphine vs gefitinib | 0.7783 to 2.011 | |||
| Morphine vs morphine + gefitinib | –2.349 to –1.117 | |||
| Figure 2B | Non-normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Morphine vs vehicle | 0.8614 to 1.635 | ||
| Morphine vs gefitinib | 0.7111 to 1.484 | |||
| Morphine vs morphine + gefitinib | –2.034 to –1.223 | |||
| Figure 2C | Non-normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Morphine vs vehicle | 0.1181 to 1.828 | ||
| Morphine vs EGF | 0.8573 to 2.567 | |||
| Figure 3A | Non-normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Morphine vs sham | –11.35 to –9.522 | ||
| Morphine vs gefitinib | –0.9836 to 0.9314 | |||
| Morphine vs morphine + gefitinib | –8.873 to –6.958 | |||
| Figure 3B | Normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Morphine vs vehicle | –1.497 to 1.603 | ||
| Morphine vs EGF-FC | –1.904 to 1.196 | |||
| Morphine vs morphine + EGF-FC | –10.45 to –7.348 | |||
| Figure 4A | Normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Vehicle vs imatinib | –1.891 to 2.498 | ||
| Vehicle vs EGF | 6.313 to 10.07 | |||
| Vehicle vs EGF+ imatinib | –6913 to 3.697 | |||
| Figure 4B | Normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Vehicle vs imatinib | –1.515 to 1.977 | ||
| Vehicle vs EGF | –1.367 to 2.126 | |||
| Vehicle vs EGF+ imatinib | –1.732 to 1.761 | |||
| Figure 4C | Normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Vehicle vs gefitinib | –1.408 to 2.104 | ||
| Vehicle vs PDGF | 4.401 to 7.913 | |||
| Vehicle vs PDGF+ gefitinib | –0.1661 to 3.346 | |||
| Figure 4D | Normally distributed | Two-way ANOVA | ||
| Dunett's multiple comparison test | Vehicle vs gefitinib | –0.921 to 1.743 | ||
| Vehicle vs PDGF | –0.9921 to 1.536 | |||
| Vehicle vs PDGF+ gefitinib | –0.606 to 2.058 |