Motor behavior in zebrafish larvae following hypoxia or normoxia, with or without exposure to a dopaminergic D4 receptor antagonist (L-745870) from 72 to 96 hpf
| Treatment | Swimming distance (mm) | Velocity (mm/s) | Rotation frequency (no/10 min) |
|---|---|---|---|
| Normoxia, n = 24, 21% pO2 | 655.4 ± 71.3 | 1.7 ± 0.2 | 54.0 ± 4.4 |
| Hypoxia 72–96 hpf, n = 24, 5% pO2 | 361.7 ± 54.1 | 0.9 ± 0.1 | 41.5 ± 5.3 |
| D4 control (0.1% DMSO), n = 12 | 581.7 ± 113.5 | 1.3 ± 0.3 | 52.1 ± 8.8 |
| D4 antagonist (L-745870), n = 12 | 282.5 ± 37.4 | 0.6 ± 0.1 | 23.4 ± 3.7 |