mGPSC frequency data (Hz) for whole-cell electrophysiology experiments
| Frequency (Hz) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group means | Mean of within cell ratio | |||||||||
| Treatment 1 | Control | Treatment 1 | Treatment 2 | Treatment 1/control | Treatment 2/control | |||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| DMSO | 40.57 | 5.22 | 37.64 | 4.87 | - | - | 0.95 | 0.04 | - | - |
| WIN | 64.98 | 13.77 | 50.50 | 12.36 | - | - | 0.74 | 0.04 | - | - |
| CNO | 48.56 | 11.04 | 41.07 | 10.01 | - | - | 0.82 | 0.04 | - | - |
| Adenosine | 42.03 | 4.63 | 33.75 | 3.80 | - | - | 0.79 | 0.05 | - | - |
| Treatment 2: WIN (3 μM) | ||||||||||
| AM251 | 57.46 | 14.60 | 54.22 | 13.32 | 53.14 | 12.32 | 0.97 | 0.06 | 0.95 | 0.03 |
| FC | 34.70 | 5.46 | 35.78 | 6.13 | 33.73 | 5.67 | 1.02 | 0.04 | 0.98 | 0.09 |
| ACPTII | 34.14 | 5.07 | 32.86 | 5.08 | 28.30 | 4.65 | 0.96 | 0.03 | 0.81 | 0.04 |
| CGS | 38.78 | 8.25 | 38.50 | 6.93 | 36.86 | 6.53 | 1.04 | 0.05 | 1.00 | 0.05 |
| DPCPX | 44.92 | 4.83 | 42.29 | 4.77 | 42.48 | 5.40 | 0.94 | 0.03 | 0.99 | 0.06 |
| Treatment 2: CNO (10 μM) | ||||||||||
| DPCPX | 39.08 | 3.25 | 37.87 | 3.79 | 34.83 | 3.01 | 0.96 | 0.04 | 0.94 | 0.07 |
The treatment/control ratio was calculated for each recorded neuron and then averaged for each treatment group.