Table 1.

CUS schedule for male and female rats

CUS procedure
Day	Males	Females
1	15-min footshock	15-min footshock
2	30-min restraint	30-min restraint
3	Social defeat	24-h lights on
4	10-min tail pinch	10-min tail pinch
5	24-h wet bedding	24-h wet bedding
6	15-min footshock	15-min footshock
7	1-h shake/overcrowding	1-h shake/overcrowding
8	Social defeat	24-h wet bedding
9	10-min tail pinch	10-min tail pinch
10	24-h lights on	24-h lights on
11	Social defeat	15-min footshock
12	10-min tail pinch	10-min tail pinch
13	24-h lights on	24-h lights on
14	15-min footshock	30-min restraint
15		24-h wet bedding
16		15-min footshock
17		10-min tail pinch
18		24-h lights on
19		1-h shake/overcrowding
20		24-h wet bedding
21		15-min footshock

Rats were exposed to one daily stressor over a series of 14 d (males) or 21 d (females). Individual stressor protocols described in further detail in the methods section.