IC40 values for (−)-menthol on (α4[L9´X])2(β2)3 mutant nAChRs
| Residue | IC30 (µm (+)-menthol ± SEM) | n |
|---|---|---|
| Ala | 855 ± 130 | 18 |
| Ser | 357 ± 62.0 | 11 |
| Gln | 117 ± 14.0 | 13 |
| Thr | 547 ± 110 | 11 |
| Cys | 162 ± 23.0 | 11 |
| Ile | 50.1 ± 11.0 | 7 |
| Met | 18.4 ± 1.60 | 10 |
| Leu (WT) | 35.6 ± 5.70 | 9 |
| Phe | 121 ± 10.0 | 10 |
| Trp | 26.6 ± 4.90 | 10 |