Table 3:

Concentration–response of ACh in the absence and presence of menthol stereoisomers on (α4)3(β2)2 and (α4)2(β2)3 nAChRs

ReceptornHIC50 (μm)nImax (μA)
1:10 (α4)2(β2)3 a
    ACh only1.27 ± 0.050.61 ± 0.0205150.04–1.05
    With (–)-menthol1.38 ± 0.080.66 ± 0.0318120.05–0.82
    With (+)-menthol1.51 ± 0.100.64 ± 0.0321150.03–0.85
10:1 (α4)3(β2)2 b
    ACh only1.74 ± 0.0799.8 ± 2.37190.2–13.6
    With (–)-menthol1.58 ± 0.04120.8 ± 2.37180.1–9.9
    With (+)-menthol1.56 ± 0.04126.4 ± 2.52190.1–9.3

  • ↵a Stimulated with 2 µm ACh.

  • ↵b Stimulated with 100 µm ACh.