IC30 values for (+)-menthol on (α4[L9´X])2(β2)3 mutant nAChRs
| Residue | IC30 (µm (+)-menthol ± SEM) | n |
|---|---|---|
| Ala | 760 ± 100 | 9 |
| Ser | 215 ± 41.0 | 11 |
| Gln | 114 ± 12.0 | 10 |
| Thr | 475 ± 47.0 | 9 |
| Cys | 108 ± 28.0 | 11 |
| Ile | 70.4 ± 18.0 | 9 |
| Met | 15.6 ± 5.50 | 15 |
| Leu (WT) | 27.1 ± 4.50 | 8 |
| Phe | 60.0 ± 12.0 | 8 |
| Trp | 11.3 ± 1.60 | 18 |