CL | Gene | # leading edge subsets | mean r | Associated cognitive function | |||
---|---|---|---|---|---|---|---|
Mems | Memw | Mots | Motw | ||||
Memory Cortical + | PRKCD | 9 | 0.10 | Y | |||
RAC1 | 9 | 0.07 | Y | ||||
HLA-DRB5 | 8 | 0.12 | Y | ||||
HLA-DRB1 | 8 | 0.09 | Y | ||||
HLA-DRB4 | 8 | 0.09 | Y | ||||
HCK | 8 | 0.09 | Y | ||||
HLA-DRB3 | 8 | 0.08 | |||||
LIMK1 | 7 | 0.13 | Y | Y | |||
CDC42 | 7 | 0.11 | Y | ||||
VAV1 | 6 | 0.15 | Y | ||||
Memory Cortical − | HIST1H4A | 23 | –0.18 | Y | Y | ||
HIST1H4E | 23 | –0.17 | Y | Y | |||
HIST1H4H | 23 | –0.13 | Y | Y | |||
HIST1H4I | 23 | –0.12 | Y | Y | |||
HIST4H4 | 23 | –0.11 | Y | Y | |||
HIST1H4J | 23 | –0.11 | Y | Y | |||
HIST1H4B | 23 | –0.10 | Y | Y | |||
HIST1H4K | 23 | –0.10 | Y | Y | |||
HIST1H4F | 23 | –0.09 | Y | Y | |||
HIST1H4D | 23 | –0.09 | Y | Y |
Candidate gene lists for the memory analysis of cortical regions, from positively and negatively correlated gene lists. Genes are ranked by the number of leading-edge subsets they appear in, and subsequently by mean r value. CL: candidate gene list; # leading-edge subsets: number of leading-edge subsets that the gene was found in; Mems: strong evidence for memory function; Memw: weak evidence for memory function; Mots: strong evidence for motor function; Motw: weak evidence for motor function; +: positively correlated candidate gene list; −: negatively correlated candidate gene list. See Extended Data Table 3-1 for the literature review supporting the cortical gene-cognition associations and Extended Data Table 3-2 for the complete LEA output for cortical analyses.