Table 1:

Detailed statistics used in different figures

Figure numberData structureType of testStatistics
Figure 1ENon-normalWilcoxon rank sum testp = 0.0048 for CVw differences between WT older and KO older
Figure 1FNon-normalWilcoxon rank sum testp < 0.001 for CVb differences between WT older and KO older
Figure 1JNon-normalTwo-way ANOVAF(1,113) = 5.78; p = 0.018 for WT vs KO differences
Figure 1LNon-normalWilcoxon rank sum testp = 0.14 for jitter slope differences between WT older and KO older
Figure 2ENormalThree-way ANOVAp < 0.001 for CVw differences between WT older and KO older
Figure 2FNormalThree-way ANOVAp < 0.001 for CVb differences between WT older and KO older
Figure 3DNormalTwo-way ANOVAF(1,100) = 4.97; p = 0.028 for WT and KO differences; F(1,100) = 8.05; p = 0.005 for interaction factor between age and genotype; p = 0.7, for WT older vs WT younger; p < 0.001 for KO older vs KO younger, t test with Bonferroni correction
Figure 3ENormalTwo-way ANOVAF(1,99) = 7.47, p = 0.007 for age factor; F(1,99) = 9.46; p = 0.003 for interaction factor between age and genotype; p = 0.0002 for KO older vs KO younger; p = 0.9 for WT older vs WT younger; p = 0.0025 for WT older and KO older
Figure 3FNormalTwo-way ANOVAF(1,92) = 6.83, p = 0.011 for interaction factor between age and genotype, F(1,92) = 2.2, p = 0.14 for age factor; p = 0.052 for WT older and KO older; p = 0.007 for KO older and KO younger; p = 0.4for WT older and WT younger
Figure 3GNormalTwo-way ANOVAF(1,100) = 4.71; p = 0.032 for spike number between WT and KO; p = 0.029 between WT old and KO old; p = 0.3 between WT young and KO young
Figure 3JNormalTwo-way ANOVAF(1,94) = 0.03; p = 0.86 for WT and KO differences
Figure 3KNormalTwo-way ANOVAF(1,923) = 0.92; p = 0.33; WT and KO differences at young age group
Figure 3LNormalTwo-way ANOVAF(1,1070) = 31.03 p < 0.001; WT and KO differences at old age group
Figure 4BNormalTwo-way ANOVAF(1,72) = 5.35; p = 0.023 for difference between WT and KO CA3 cells younger animals
Figure 4DNormalTwo-way ANOVAF(1,88) = 1.06; p = 0.31 for difference between WT and KO CA1 cells younger animals
Figure 4FNormalTwo-way ANOVAF(1,75) = 1.16; p = 0.28 for difference between WT and KO CA3 cells older animals
Figure 4HNormalTwo-way ANOVAF(1,59) = 7.42; p = 0.009 for difference between WT and KO CA1 cells for older animals
Figure 5CNormalTwo-way ANOVAF(1,46) = 4.8; p = 0.033 for mAHP WT and KO differences. p = 0.2 between WT younger and KO younger; p = 0.018 for WT older and KO older
Figure 5DNormalTwo-way ANOVAF(1,54) = 8.84; p = 0.004 for sAHP WT and KO differences; p = 0.07 between WT younger and KO younger; p = 0.008 for WT older and KO older
Figure 5FNon-normalWilcoxon rank sum testp = 0.91 for Ih percentage of sag between WT and KO
Figure 5HNormalTwo-way ANOVAF(1,258) = 2.54; p = 0.11 between WT and KO for IM current
Figure 6CNormalTwo-way ANOVAF(1,240) = 33.3; p < 0.001 for WT older and KO older SK currents
Figure 6DNormalTwo-way ANOVAF(1,189) = 0.51; p = 0.5 for WT younger and KO younger SK currents
Figure 6ENormalTwo-way ANOVAF(1,229) = 0.01; p = 0.9 for WT older and WT younger SK currents
Figure 6FNormalTwo-way ANOVAF(1,209) = 21.02; p < 0.001 for KO older and KO younger SK currents
Figure 7BNormalTwo-way ANOVAF(1,24) = 0.48; p = 0.5 for WT younger vs KO younger for CA3
Figure 7CNormalTwo-way ANOVAF(1,24) = 0.21; p = 0.6 for WT younger vs KO younger for CA1
Figure 7DNormalTwo-way ANOVAF(1,24) = 0.3; p = 0.6 for WT older vs KO older for CA3
Figure 7ENormalTwo-way ANOVAF(1,24) = 0.25; p = 0.61 for WT older vs KO older for CA1
Figure 8ENormalTwo-way ANOVAF(1,48) = 0; p = 0.96 for effect of apamin; F(1,49) = 8.74; p = 0.005 for WT and KO differences
Figure 8FNormalTwo-way ANOVAF(1,96) = 157.5; p < 0.001 for WT and KO differences; F(1,96) = 53.1; p < 0.001 for effect of apamin on CVb
Figure 8GNormalTwo-way ANOVAF(1,49) = 9.63; p=0.003 for WT and KO differences; F(1,49) = 2.87; p = 0.09 for effect of apamin; p = 0.006 for WT pre apamin and KO pre apamin; p = 0.05 for KO pre apamin and KO post apamin; p = 0.23 WT pre apamin and KO post apamin
Figure 8HNormalTwo-way ANOVAF(1,41) = 2.1; p = 0.15 for effect of apamin; F(1,41) = 3.6; p = 0.06 for WT and KO differences
Figure 8INormalTwo-way ANOVAF(1,81) = 2.7; p = 0.1 for differences between WT and KO; F(1,81) = 40.5 p < 0.001 for effect of BAPTA
  • It is to be noted that all of the data in figures is from CA1 cells except in Figure 4, where it is from both CA3 and CA1 cells