Data structure | Type of test | Statistics | |
---|---|---|---|

a | Normal distribution | One-tailed unpaired t test | Patient 1: t_{(598)} = 3.286, p < 0.001Patient 2: t_{(598)} = 2.762, p = 0.003Patient 3: t_{(598)} = 3.013, p = 0.001Patient 4: t_{(598)} = 4.644, p < 0.001Patient 5: t_{(598)} = −1.241, p = 0.108Patient 6: t_{(338)} = −3.852, p < 0.001Patient 7: t_{(598)} = 0.743, p = 0.771Patient 8: t_{(598)} = −1.763, p = 0.039 |

b | No assumption | One-tailed permutation test | p = 0.009 |

c | No assumption | Two-tailed permutation test | p = 0.627 |

d | Approximate normal distribution | Two-tailed unpaired t-test | t_{(14)} = 0.749, p = 0.466 |