Table 7.

The effect of age, the genotype–age interaction and the effect of genotype on the silhouette parameters and gait parameters: mixed ANOVA and multiple-comparison tests with Bonferroni correction (p values with lower bound adjustment)

	Rats			Mice
Parameters	Age	Interaction	Genotype	Age	Interaction	Genotype
Stride lengths
Front-paw stride length (cm)	<0.0001	0.46	0.01	0.005	0.25	0.03
Hind-paw stride length (cm)	<0.0001	0.54	<0.01	0.004	0.24	0.03
Scaled front-paw stride length^*	0.60	0.58	0.046	0.013	0.17	0.90
Scaled hind-paw stride length^*	0.53	0.67	0.02	0.01	0.17	0.94
Speed parameters
Body speed (cm/s)	0.01	0.55	0.26	0.004	0.25	0.03
Front-paw swing speed (cm/s)	<0.001	0.43	0.35	0.004	0.43	<0.01
Hind-paw swing speed (cm/s)	<0.001	0.59	<0.01	0.003	0.47	<0.001
Scaled body speed (1/s)^*	0.16	0.51	0.47	0.007	0.25	0.18
Scaled front-paw swing speed (1/s)^*	0.13	0.41	0.65	0.007	0.45	0.11
Scaled hind-paw swing speed (1/s)^*	0.11	0.60	0.01	0.007	0.47	<0.01
Body parameters
Silhouette length (mm)	<0.0001	0.23	0.03	0.012	0.10	<0.0001
Silhouette area without tail (mm²)	<0.0001	0.15	<0.001	<0.001	0.26	<0.0001
Silhouette area with tail (mm²)	<0.0001	0.26	<0.01	<0.01	0.14	<0.0001
Weight (g)	<0.0001	0.20	0.03	<0.0001	0.35	<0.0001
Weight silhouette length index (g/cm²)	<0.0001	0.17	0.29	<0.001	0.55	<0.001

↵* Scaled based on the silhouette length (scaling method: ).