Stimulation patterns tested in model simulations, healthy (intact) animals, and 6-OHDA-treated animals
| Pattern | Model | Bar test | Open field test | Adjusting steps test | Forelimb use asymmetry test | Skilled forelimb reaching test |
|---|---|---|---|---|---|---|
| Intact animals | ||||||
| No stimulation | X | 7 | 9 | 8 | 5 | 8 |
| Irregular β | X | 5 | 5 | 7 | 5 | 5 |
| B15 IBF225 | X | 5 | 6 | 7 | 3 | 6 |
| B20 IBF225 | X | 5 | 5 | 5 | 5 | |
| B25 IBF225 | X | 5 | 6 | 7 | 3 | 6 |
| Regular 15 Hz | X | 7 | 8 | 6 | 3 | 5 |
| Regular 20 Hz | X | 5 | 5 | 5 | 5 | |
| Regular 25 Hz | X | 5 | 6 | 7 | 6 | |
| Regular 225 Hz | X | 7 | 9 | 7 | 3 | 5 |
| 6-OHDA-treated animals | ||||||
| No stimulation | X | 9 | 5 | 6 | 3 | 4 |
| Regular 130 Hz | 9 | 5 | 3 | 3 | 3 | |
| 6-OHDA levodopa + stimulation experiments | ||||||
| Levodopa (LD) | 3 | 3 | ||||
| LD + irregular β | 3 | 3 | ||||
| LD + B15 IBF225 | 3 | 3 | ||||
| LD + B20 IBF225 | 3 | 3 | ||||
| LD + B25 IBF225 | 3 | 3 | ||||
| LD + regular 15 Hz | 3 | 3 | ||||
| LD + regular 20 Hz | 3 | 3 | ||||
| LD + regular 25 Hz | 3 | 3 | ||||
| LD + regular 225 Hz | 3 | 3 | ||||