Table 1.

Studies of the effects of a HFD on APOE3 and APOE4 mice

ReferenceOnset/durationSexDietary compositionMetabolic findingsCognitive findings
Arbones-Mainar et al. (2008)2 months/8 weeksMale21% (w/w) fat and 0.2% (w/w) cholesterol
  • • Weight gain: E3 HFD > E4 HFD

  • • SAT accumulation: E3 HFD = E4 HFD

  • • VAT accumulation: E3 HFD > E4 HFD

  • • Baseline glucose: E3 HFD = E4 HFD

  • • Glucose intolerance: E4 HFD > E3 HFD

N/A
To et al. (2011)3 months/32 weeksMale60% kcal fat from lard
  • • Baseline glucose: E3 HFD = E4 HFD

  • • Glucose intolerance: E3 HFD = E4 HFD

N/A
Huebbe et al. (2015)6–8 weeks/8 monthsFemale21% fat from milk
  • • Weight gain: E3 HFD > E4 HFD

N/A
Arbones-Mainar et al. (2016)2 months/1–10 monthsMale21% (w/w) fat from milk and 0.2% (w/w) cholesterol 
  • • Weight gain: E3 HFD > E4 HFD

  • • Baseline glucose: E3 HFD = E4 HFD

N/A
Johnson et al. (2017)9 months/6 monthsFemale60% kcal fat from lard
  • • Weight gain: E3 HFD > E4 HFD

  • • VAT accumulation: E3 HFD > E4 HFD

  • • Baseline glucose: E3 HFD = E4 HFD

  • • Glucose intolerance: E4 HFD > E3 HFD

  • • Object recognition impairment: E3 HFD = E4 HFD

  • • Cued fear memory: E3 HFD = E4 HFD

  • • Spatial memory: E4 HFD > E3 HFD

Johnson et al. (2019)9 months/6 monthsFemale60% kcal fat from lard
  • • Weight gain: E3 HFD > E4 HFD

  • • SAT accumulation: E3 HFD = E4 HFD

  • • VAT accumulation: E3 HFD > E4 HFD

  • • Baseline glucose: E3 HFD = E4 HFD

  • • Glucose intolerance: E3 HFD = E4 HFD

  • • Morris water maze: E3 HFD = E4 HFD