Table 1.

Electrophysiological parameters measured for CA1 hippocampal pyramidal cells at time 0 for all experimental treatments

	Vehicle			BSA			44 nM oTau			133 nM oTau			444 nM oTau
Parameter	Mean	SEM	SD	Mean	SEM	SD	Mean	SEM	SD	Mean	SEM	SD	Mean	SEM	SD
C (pF)	121.8	± 12.56	± 62.8	125.6	± 14.17	± 34.43	132.55	± 17.65	± 79.43	105	± 8.04	± 44.22	125.3	± 14.31	± 71.55
R in (MΩ)	164.4	± 12.22	± 61.1	183.6	± 21.13	± 52.83	157.89	± 23.01	± 103.55	180.36	± 20.42	± 112.31	176.8	± 4.74	± 23.7
τ (ms)	20.72	± 1.75	± 8.75	15.72	± 0.89	± 2.23	16.67	± 1.86	± 8.37	15.24	± 1.40	± 7.7	19.63	± 2.25	± 1.25
E (mV)	–67.2	± 1.16	± 5.8	–68.5	± 1.34	± 3.35	–69.63	± 0.91	± 4.10	–66.22	± 1.06	± 5.83	–64.95	± 2.0	± 10
V T (mV)	–50.07	± 0.68	± 3.4	–52.69	± 1.26	± 3.15	–54.8	± 0.984	± 4.43	–50.67	± 1.35	± 7.43	–50.92	± 1.49	± 7.45
ΔT (mV)	0.77	± 0.036	± 0.18	0.82	± 0.063	± 0.16	0.97	± 0.15	± 0.68	0.87	± 0.1	± 0.55	0.89	± 0.08	± 0.4
Action potential Amplitude (mV)	75.8	± 4.87	± 24.35	83.6	± 1.84	± 4.6	86.11	± 1.59	± 7.16	77.91	± 2.82	± 15.51	82.66	± 1.9	± 9.5
Duration (ms)	1.42	± 0.093	± 0.465	1.48	± 0.07	± 0.18	1.28	± 1.31	± 5.90	1.41	± 0.07	± 0.385	1.44	± 0.053	± 0.265
Rise (mV/ms)	249.4	± 30.54	± 152.7	288.4	± 17.8	± 44.5	318.8	± 26.55	± 119.48	252.7	± 23.68	± 130.24	282.11	± 21.85	± 109.25

See Extended Data Table 1-1 for the mean, SEM, and SD for all other recorded parameters.