Table 1.

Statistical table

	Comparison	Data structure	Type of test	Mean diff. (95% CI)
a	PSD95, EAE-V versus Sham-V	Normal	One-way ANOVA, Sidak post hoc	–0.24 (–0.45 to –0.02)
b	PSD95, EAE-099 versus EAE-V	Normal	One-way ANOVA, Sidak post hoc	0.25 (0.01 to 0.48)
c	EAE score (IHC cohort), EAE-099 versus EAE-V	Non-parametric	Mann–Whitney U test	–0.5 (–2.5 to 0.5)^*
d	EAE score (conditioning cohort), EAE-099 versus EAE-V	Non-parametric	Mann–Whitney U test	–1 (–1 to 0)^*
e	Microglia SA:volume, EAE-V versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	–0.98 (–1.54 to –0.43)
f	Microglia SA:volume, EAE-099 versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	–1.09 (–1.64 to –0.53)
g	Microglia SA:volume, EAE-1134 versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	–0.81 (–1.33 to –0.28)
h	Iba1, EAE-099 versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	0.44 (0.05 to 0.82)
i	CD68, EAE-V versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	0.73 (–0.26 to 1.71)
j	iNOS, EAE-V versus Sham-V	Normal	One-way ANOVA, Sidak post hoc	0.93 (0.29 to 1.57)
k	iNOS, EAE-099 versus EAE-V	Normal	One-way ANOVA, Sidak post hoc	–0.61 (–1.23 to –0.01)
l	FcyR1-CD64, EAE-V versus Sham-V	Normal	One-way ANOVA, Sidak post hoc	0.56 (0.16 to 0.95)
m	Pro-IL1β, EAE-V versus Sham-V	Normal	One-way ANOVA, Sidak post hoc	0.87 (–0.02 to 1.77)
n	CD86, EAE-099 versus EAE-V	Normal	One-way ANOVA, Sidak post hoc	–0.22 (–0.39 to –0.05)
o	Iba1, EAE-V versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	5.69 (0.63 to 10.75)
p	Iba1, EAE-099 versus EAE-V	Normal	One-way ANOVA, Tukey post hoc	7.75 (3.27 to 12.24)
q	C1q, EAE-V versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	2.63 (0.62 to 4.63)
r	C1q, EAE-099 versus Sham-V	Normal	One-way ANOVA, Tukey post hoc	3.01 (1.37 to 4.65)
s	Neuronal apoptosis, 100 nM 099 versus vehicle (24 h)	Normal	One-way ANOVA, Sidak post hoc	–37.0 (–23.2 to –50.8)
t	Neuronal apoptosis, 300 nM 099 versus vehicle (24 h)	Normal	One-way ANOVA, Sidak post hoc	–38.2 (–24.4 to –52.0)
u	Neuronal apoptosis, 100 nM 099 versus vehicle (48 h)	Normal	One-way ANOVA, Sidak post hoc	–40.8 (–27.0 to –54.6)
v	Neuronal apoptosis, 300 nM 099 versus vehicle (248 h)	Normal	One-way ANOVA, Sidak post hoc	–53.9 (–40.1 to –67.7)
w	P Ser 73 JUN, 099 versus vehicle (8h)	Normal	One-way ANOVA, Sidak post hoc	–0.80 (–0.14 to –1.45)
x	P Ser 73 JUN, 099 versus vehicle (12h)	Normal	One-way ANOVA, Sidak post hoc	–0.99 (–0.33 to –1.64)
y	Context Δ freeze, EAE-V versus Sham-V (treatment main effect)	Normal	Two-way ANOVA, Sidak post hoc	–0.33 (–0.61 to –0.05)
z	Context Δ freeze, EAE-099 versus EAE-V (treatment main effect)	Normal	Two-way ANOVA, Sidak post hoc	0.32 (0.02 to 0.62)

↵* Mann–Whitney U test results reported for days with greatest mean difference between group scores (IHC cohort: days 5–6; fear conditioning cohort: days 10–12).