Table 1.

Basal levels of dopamine, dopamine metabolites, and ACh

MouseBrain regionDADOPACHVAACh
(fmol/sample)(pmol/sample)(pmol/sample)(fmol/sample)
WTNAc41.28 ± 5.47 (22)5.725 ± 0.592 (21)12.73 ± 2.49 (15)nd
p11 KO (constitutive p11 KO)NAc42.35 ± 6.31 (17)5.777 ± 0.917 (16)13.57 ± 2.47 (9)nd
WTPFC12.00 ± 4.44 (8)0.894 ± 0.121 (7)4.863 ± 1.447 (3)nd
p11 KO (constitutive p11 KO)PFC6.35 ± 1.77 (7)1.020 ± 0.142 (7)5.143 ± 0.743 (4)nd
WT (ChAT-cre-/- P11flox/flox)NAc46.72 ± 9.94 (8)6.549 ± 1.264 (8)nd428.7 ± 75.65 (12)
ChAT p11 cKO (ChAT-cre P11flox/flox)NAc64.13 ± 11.63 (8)6.485 ± 0.857 (8)nd557.0 ± 116.6 (8)
ChAT p11 cKO + AAV-YFPNAc29.19 ± 6.45 (8)ndndnd
ChAT p11 cKO + AAV-p11NAc35.35 ± 10.08 (8)ndndnd
ChAT p11 cKO + AAV-mCherryNAc54.18 ± 21.21 (6)ndndnd
ChAT p11 cKO + AAV-rM3D (Gs)NAc50.77 ± 22.85 (6)ndndnd
ChAT p11 cKO + AAV-mCherryNAc117.8 ± 37.19 (8)ndndnd
ChAT p11 cKO + AAV-hM4D (Gi)NAc77.90 ± 21.02 (13)ndndnd
  • Data represent mean ± SEM. The numbers of experiments are shown in the parentheses.

  • DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; ACh, acetylcholine; nd, not determined.